Acetylcholine/Choline Deficiency in Chronic Illness – The Hunt for the Missing Egg

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Managing methylene bridge cysteine is only 1 aspect of the foundational aspects of the systems presented here. Methylene bridge cysteine at or lower thant 6 or 7 um/L is one objective because methylene bridge cysteine deteriorates and sequesters flowing hydridic current, redox factors and the quantum energies that enable atom level structure.

The second priority is to assure available of methylene bridges that are not cysteinylated, because this enables the production of fatty acids, methyl groups, NAD, NADP, DNA RNA and foundational polymerization processes that translate current hydride, excited electrons or electrons excided from the photoelecric effect, all into structure. S-adenosylmethionine, phosphatidylethanolamine, NOPE1, NOPE2(fatty acid enabled phosphatidylethanolamine), phosphatidylcholine, DNA, omega-3 fatty acids, all are factors to use in this regard. Ethanolamine is an essential exogenously obtain nutrient as are all of the amino acids not endogenously synthesized known as the essential amino acids. Ethanolamine is recycled, but the posts or the hydrogens in CH2 methyelene bridges can wear out or structurally deteriorate like the an automobile battery, so the ethanolamine must be obtained consistently.

A typical lecithin supplement has a diverse array of phospholipids including phosphatidylethanolamine, and are good as a “daily bread” to resupply current infrastructure for efficient redox.

Finding the factors that diminish PEMT is important, that means, covering the power outlets in the home and using EMF coverings for all EMF or appliances and devices in the home. Start with covering power outlets and plugging appliances in through the tape or coverings. Obtain devices or coverings for devices and applicants to block, absorb or dissipate RF or EMF. RF and EMF are emitted by humans especially correlative to their exposure to EMF or RF, are exhibited in nature, and are exchanged by humans, devices and environmental fields, including the earth’s magnetic fields and celestial/lunar/solar sources. These are why housing and shelter, insulation, deep earth linkages to power infrastructure, all are important, although daily exposure to the earths magnetic fields at night and solar influences in the daytime, with possible participation of lunar influences, all can be essential in recycling NAD, energy infrastructure,and current. Daily sources of intended influences while also implementation of housing and shelter, all are balances derived from nature.

Also, the reason that vitamins and phytochemicare so important is that they supply current, hydride or hydridic potentiators and these fuel the carbocation activity through which molecules release fluorescent energy or 2 eV-, that enables biological activity, turns proteins into enzymes, promote alkane alkalinity that trans proteins into enzymes, and supplies energy to the environment for biological activity. A complete B vitamin with all B vitamins,B12 methylcobalamin, B6, Niacin in particular, folate, methylene tetrahydrofolate,6s 5678 tetrahydrofolate, trimethylglyine/Betaine/Beetpowder,, and/or a product such as Niagen that enables synthesis of NAD, while melatonin can help supply and recycle NAD using circadian rhythms.

The metals in vitamins also participate in magenetic interactions with systems outside of physiology to exchange current and fields in a way that enhances sustainability of redox systems.

The older one becomes, the more like that pathways that use B12 may become impaired, such that folate accumulation and B12 accumulation in circulatory fluids are linked to increasing age. The factors mentioned in the preceding paragraph open up these pathways and allow one carbon pathway metabolism to be used, such that one more pathway element becomes required.

This pathway includes going to the website where this research is presented and finding and alleviating the factors that diminish PEMT. The easiest ones are AP1 and SP! and Berberine along with Curcumin are useful, although pharmacological modulators AP1 and SP1 are available. These are strongly effective against pervasive pathology. These also inhibit NOS2 inducible.

Rubisco supplements or green leafy vegetables along with vitamin K2, can enhance hexose monophosphate shunt which reenables production of nucleotides along with availability of ethanolamine or methylene bridges.

A supplement that has diverse hexose sugars is optimal, including as a substitute for only glucose in flavorings. This is because not all hexose sugars are blocked by P53 during injury, impairment or downregulation of PEMT. Ribose is important because it supplies PARP with substrate to prevent its depletion of NAD+, Nucleotide supplements also prevent PARP from depleting NAD+. Niagen and Melatonin also enhance availability of NAD+. Availability of all the factors in the paragraph enable synthesis of nucleotides, enables parp to dissociate from the location of DNA impairment which enables optimal homologous perfect DNA repair. Also, providing these factors disables PARP as a major source of methylene bridge cysteine from nicotinamide methyltransferases as well as prevents a major foundational metabolic impairment that depletes NAD+, increases lactate anion, and deprives other pathways of pyruvate distribution from being deficient.

Once you begin focusing on alleviating the factors that downegulate methylene bridge cysteine, the faction of homocysteine produced by a functional PEMT pathways is not linked to disease.

However, it is very important to use either 33dmb, grapeseed oil, olive oil, balsamic vinegar, along with Probiotic/macrobiotic/postbiotic or broad spectrum antibiotic during an emergency to mange TMAO which is the most pervasive cause of any adverse health event or behavior.

Also mentioned should be the use of Active Hexose Correlated Compound in Latent disease vectors and other diseases because it is a choline kinase regulator and it activates the hexose monophosphate shunt bu shunting in substrates that are downregulated by P53, injury, impairment and downregulated PEMT. Regular laxatives also help clear digestive pathways of TMAO enabling factors. Bioloagically active foods, drinks, yogurts, and other capbilities have emerged in this area of therapeutics and nutrition. Although meat chicken, eggs and fish enable TMAO, there are now leaky gut supplements that are useful in this context.

Leaky gut supplements are mentioned here because sources of extracellular matrix, agrin, and laminin all enhance how these factors begin to produce regenerative effects and began regressing the effects of disease, inadequate nutrition, toxic influence or factor exposure, a detrimental factors linked with aging. Best sources of agrin include bone powder, methyl sulfonyl methane, and whole organism glandular supplement that is highly granular to prevent accumulation in digestive pathways. Agrin, laminin, whole animal glandular with leaky gut protection, methyl sulfonyl methante, enriched phosphatidylcholine, vitamin U or s methylmethionine Sulfonium, Vitamin D3 and Calcium, together make it really difficult for disease of the bone to persist while an inhibitor of NOS2 such as curcumin, ablates NOS2 as a cause of sytemic depletion of calcium and nturtients from bone. EMF protection elminates an integral cause of such conditions by preventing NOS2, phospholipase D and phosphatidylcholine specific phospholipase C.

Regardless of if you begin at the beginning, middle or conclusion of this specific list in this specific posting of information, together these provide a strong foundation for the elimination and management of any physiological or behavioral impairment. Work closely with your physician or find a health profession who most strongly believes that things happen for a reason, believes that outcomes have causality, and whom are willing to explore the causal factors of diminished and optimal outcomes, and use their knowledge, experience, wisdom, access, tools and willingness to improve human outcomes to our advantage in these contexts. There are pharmacological and therapeutics in conventional, wholistic and alternative medicine that can be applied in this regard. The objectives, pathways and strategy are most important, such that the variance in experience, perspectives and capabilities can produce even more powerfully successful outcomes in this regard.

A summarization of therapeutic recommendations for Viral conditions, including clearance of viral pathogens linked to disease, as well as pathologies ubiquitously is presented, again. 

These factors may comprise ubiquitously effective solution, although nearly existing 130 factors are outstanding. These factors are relevant for minor conditions, allergies, chronic conditions, impairment, autism, detrimental behavior. psychiatric conditions, pyschological conditions, genetic conditions, complications, risk for perioperative complications, etc.

Add these factors in order, observing the affect of each additional factor. HPV, HIV, most any viral condition, oncology, and pervasive disease are relevant to this info.

This information is relevant to prevent and reverse the adverse effects of aging. It is also relevant for regeneration of anatomy including reconstituted impaired neurological, muscular and other function, including congenital disease. This information is also relevant for myasthenic conditions including parkinson’s disease, etc.

Avoid Milk and dairy unless its made from or constituted of A2 Milk.
Avoid meat, chicken, eggs and fish unless its micronized and probiotics and prebiotics are utilized with these.
Probiotic, Prebiotic, Postbiotic and live, living foods.
Focus on nonGMO organic foods.
Every night before sleep, a prebiotic, Grapeseed Oil, extra virgin fruity polyphenol enriched olive oil or Balsamic Vinegar.
Curcumin or an SP1 inhibitor.
Berberine or an AP1 inhibitor.
Active Hexose Correlate Compound AHCC or an inhibitor of Choline Kinase alpha.
Active Hexose Correlated Compound AHCC or an inhibitor of iNOS inducible Nitric oxide Synthase.
Danshen, Red Sage or Salvia M in pill or tablet versions.
S-methylmethionine Sulfonium or a product known as Gastromend HP.
Methylsulfonylmethane or MSM.
A complete B vitamin with B12 Methylcobolamin included.
Trimethylglycine or N,N,N Glycine Betaine.
The product EnlyteRX.
L-arginine.
Tetrahydrobiopterin.
6s 5678 Tetrahydrofolate.

It also becomes essential to supply foundational aspects of cellular function, lipids and cholesterol not made or produce in a laboratory.
A mixture of grapeseed oil, extra virgin fruity olive oil, blackseed oil, mixed together along with sesame seed oil if the sesame seed oil does not cause allergies. Several ounces in the morning and several ounces in the evening.

It may help to cover the electricity plugins or outlets in dwellings with duct tape or inflammation resistent Tape.
Using Faraday enclosures or EMF covering for electronic devices, appliances, as bedding and sleepwear can be helpful.

An air purifier also can assist in lower levels of systemic inflammation.

To counteract aging or extend this list as necessary.

Pregnenolone counteract diminished star protein provision of shielded transfer for cholesterol to the mitochondria.
Phosphatidylserine complex from vitamin shoppe(phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine, phosphatidylinositol).
Phosphatidylcholine at least 400 mg.
Dr Scheussler’s Salts all 12 combined.
Whole animal glandular/matrix supplement.
Bone Powder Supplement.
Agrin Supplement, Graft or Injection, although agrin promotes regeneration along with interleukin 11, such that the signaling invoked by Agrin can enhance cellular proliferation requiring that it be omitted if oncology exists. However, matrix deterioration, scaring and stiffness as well as inadequate obtainment of lipids and cholesterol not made in a laboratory are major foundational conditions for disease and oncology because these cause persistent inflammatory signaling and involve al aspects of physiology. Mini Agrin is better along with apoptosis inhibiting drugs or apoptosis inhibition generally to enable regeneration of neurological, muscular, pathways, function, including congenital conditions.
Matrix Electrolyte Powder.
These may be helpful without utilizing the list to analyze all of the indicators with regard to the condition or circumstance an individual may have. Although, using the list oneself and with a clinician is best because this allows a professional who is focused on managing, understanding and monitoring these to work for you in an efficient manner.
 
Eradicating HIV and other latent viral factors.

These suggest that Istodax, Ingenol Mebutate, Panobinostat and Bryostatin, together may have broad enough coverage to cause HIV latency clearance.
HDAC Inhibitors and Histone Methylation Inhibitors may be effective.
However, stabilization of stabilization of the G4 quadruplex using TMPyP4, BRACO-19 and TRIM22 along with these may be especially effective.
Protein Kinase C inhibitors generally may by effective.
Inhibitors of SP1 may be particularly useful, including TRIM22 but also including pharmacological inhibitors as well as curcumin or berberine.
Ingenol Mebutate along with JQ1 latency reversal factor that is small molecular bromodomain inhibitor.

The utilization of CRISPR Genome editing capabilities to eliminate viral and latent viral affliction, as well as repair genetic disease and alleviate accumulated genetic impairment, particularly when utilized with transduction domains that enable therapeutics to permeate all cellular types with the efficiency of a water molecule, may be indispensable in this regard and there should be galvanization of populations to have such therapies rapidly developed. 

General Viral Affliction linked to disease. RNA polymerase inhibition.
Artichoke, Favipiravir, or Cidofovir or other.

Information. Ebiomedicine. Volume 63. Number 103159. 2021. PMID 33340992. 

These factors may comprise ubiquitously effective solution, although nearly existing 130 factors are outstanding. These factors are relevant for minor conditions, allergies, chronic conditions, impairment, autism, detrimental behavior. psychiatric conditions, pyschological conditions, genetic conditions, complications, risk for perioperative complications, etc.
Add these factors in order, observing the affect of each additional factor. HPV, HIV, most any viral condition, oncology, and pervasive disease are relevant to this info.
This information is relevant to prevent and reverse the adverse effects of aging. It is also relevant for regeneration of anatomy including reconstituted impaired neurological, muscular and other function, including congenital disease. This information is also relevant for myasthenic conditions including parkinson’s disease, etc.

Avoid Milk and dairy unless its made from or constituted of A2 Milk.
Avoid meat, chicken, eggs and fish unless its micronized and probiotics and prebiotics are utilized with these.
Probiotic, Prebiotic, Postbiotic and live, living foods.
Focus on nonGMO organic foods.
Every night before sleep, a prebiotic, Grapeseed Oil, extra virgin fruity polyphenol enriched olive oil or Balsamic Vinegar.
Curcumin or an SP1 inhibitor.
Berberine or an AP1 inhibitor.
Active Hexose Correlate Compound AHCC or an inhibitor of Choline Kinase alpha.
Active Hexose Correlated Compound AHCC or an inhibitor of iNOS inducible Nitric oxide Synthase.
Danshen, Red Sage or Salvia M in pill or tablet versions.
S-methylmethionine Sulfonium or a product known as Gastromend HP.
Methylsulfonylmethane or MSM.
A complete B vitamin with B12 Methylcobolamin included.
Trimethylglycine or N,N,N Glycine Betaine.
The product EnlyteRX.
L-arginine.
Tetrahydrobiopterin.
6s 5678 Tetrahydrofolate.
It also becomes essential to supply foundational aspects of cellular function, lipids and cholesterol not made or produce in a laboratory.
A mixture of grapeseed oil, extra virgin fruity olive oil, blackseed oil, mixed together along with sesame seed oil if the sesame seed oil does not cause allergies. Several ounces in the morning and several ounces in the evening.
It may help to cover the electricity plugins or outlets in dwellings with duct tape or inflammationproof Tape.
Using Faraday enclosures or EMF covering for electronic devices, appliances, as bedding and sleepwear can be helpful.
An air purifier also can assist in lower levels of systemic inflammation.

To counteract aging or extend this list as necessary.

Pregnenolone counteract diminished star protein provision of shielded transfer for cholesterol to the mitochondria.
Phosphatidylserine complex from vitamin shoppe(phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine, phosphatidylinositol).
Phosphatidylcholine at least 400 mg.
Dr Scheussler’s Salts all 12 combined.
Whole animal glandular/matrix supplement.
Bone Powder Supplement.
Agrin Supplement, Graft or Injection, although agrin promotes regeneration along with interleukin 11, such that the signaling invoked by Agrin can enhance cellular proliferation requiring that it be omitted if oncology exists. However, matrix deterioration, scaring and stiffness as well as inadequate obtainment of lipids and cholesterol not made in a laboratory are major foundational conditions for disease and oncology because these cause persistent inflammatory signaling and involve al aspects of physiology. Mini Agrin is better along with apoptosis inhibiting drugs or apoptosis inhibition generally to enable regeneration of neurological, muscular, pathways, function, including congenital conditions.
Matrix Electrolyte Powder.

These may be helpful without utilizing the list to analyze all of the indicators with regard to the condition or circumstance an individual may have. Although, using the list oneself and with a clinician is best because this allows a professional who is focused on managing, understanding and monitoring these to work for you in an efficient manner.

The information presented here was probably more complex than necessary, although an ancillary objective was to provide enough detail to enable a clinician to review what a patient or other individual might have encountered within the information presented.

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“Clearly, management or inhibition of homocysteine, s adenosyl homocysteine, AP1, SP1, iNOS, uncouple NOS and Cholilne Kinase, using Active Hexose Correlated Compound as well as therapeutics, supplements, neutraceuticals or other mechanisms of managing these may eradicate HPV, destabilize or eradicate HIV, may be prevent or eradicate pervasive other viral conditions, parasites fungal conditions, microbial or bacterial affliction, an expansive group of oncology versions that even includes voluminous oncology conditions that are not linked to microbial affliction.” This list, although possibly nearly 100 percent effective is likely to change since the review is only at indicator list item 4 or 130 and only has analyzed subset of linked conditions and has only analyzed a focused set of the data and literature for each condition. Stay tuned.
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Importantly, do get better information, review the translationalwellness.com site because in the next few paragraphs, a simplistic group of things to do will be presented that will be qualified with some, interesting and to many readers possibly difficult to believe information. Only a small amount this controversial but true information will be presented here to qualify the recommendations.

Right now, during the development of level 5 artifacts at translationalwellness.com, the 130 or more indicators or causal factors of disease and detrimental outcomes have been correlated to their relevance in disease and link to factors that inhibit as well as upregulated or modulate each indicator in the list present as level 1 and level 2 indicator list artifacts. Level 5 presents this same list of 130 factors in tabular structure as elements of a column or list, while diseases, toxins and detrimental outcomes are listed in the columns adjacent to the list. Interestingly, at this juncture only 4 clinical indicators have analyzed in the context of 3 conditions or disease, but because of the remarkable results, many similar disease and diverse other disease were rapidly reference cursorily to see how expansive these none other than pivotal results for the first few indicators really may be.

HPV was used as one of the first group of factors reviewed because it is so intricately and comprehensive characterized in the literature and data. HIV was included because it exhibits an insight laden paradox that is relevant to pervasive viral conditions and disease. The other factors included in the first group of analysis were selected and will be selected in a manner that exhibits homologous contexts and divergence nuances that lead the way to understand large aspects of the conditions and outcomes exhibited among populations. No clear plan to produce a taxonomy from such linkages, homologues and divergence, although this might emerge as an essential capability.
Regards.

The analysis clearly demonstrates the fourth factor, pretty much every disease falls apart and becomes simply explainable using a canonical module of PEMT inhibition, mitochondrial seperation from the endoplasmic reticulum, Parp signaling, transcription cascade by AP1, transcriptional silencing to produce latent disease by SP1, upregulation PD1/PDL1 by SP1 to cause disease cellular entities to hide from immunological monocytes, along with homocysteine upregulation apoptosis and a response to this by upregulation of survival pathways that become oncology because this survival response becomes persistent due to SP1 enable latency and SP1 enabled hiding of disease cellular entities. Choline kinase upregulation which is required in all disease as well as iNOS upregulation and uncoupling were added, although the analysis of each disease has not reach that row in the list of inidcators, because active hexose correlated compound has emerged as an iNOS inhibitor and an inhibitor of choline kinase.

Clinicalfactor Disease/toxicfactor/outcome1 Disease/toxicfactor/outcome2 ” ” ”
1.Clinicalfactor HIV HPV
2 Homocysteine hcy 1 (essential and causal) 1 (essential and causal )
3 s adenosyl hcy 1 1
4 AP1 1 1
5 SP1 1 (latency factor) 1 (latency factor)
6 (outoforder, iNOS) 1 1
7(ooouncoupled iNOS) 2(causal, latency correlated) 2 (causal and latency correlated)

6 and 7 were added because active hexose correlated compound modulates these.

Remarkably, when we applied these mechanisms in cursory review of diverse viral disease, even the bacteria analyzed, and parasites reviewed, as well as disease such influenza, general oncology, etc, the disease fell apart like a house of cards, almost suggesting that the disease should no longer exist or should not have existed, particular in the modern era.

HIV, for instance, was analyzed in the context of TB. Instrumentation of Active Hexose Compound occurred at 3 g for about 6 months, although another study is in place now that reviews 6 g per day dosages. The study did not intend to therapeutically affect HIV but improve TB outcomes and therapeutics toxicity.

All clinical symptoms among the HIV/TB group were improved by month 3. There were 0 patients among 35 with cough or hemoptysis. 100 percent of AHCC receiving patients had improvement in breathing depth impairment. 100 percent of AHCC receiving patients had complete recovery of impaired appetite. 96 percent of patients had recovered lost anatomical mass that was diminished during the course of the disease. Nausea was completed abrogated from the group of patients receiving AHCC. Regurgitation was completely abrogated in the group receiving AHCC. Pulmonary structural assay using visualization diagnostics revealed that although improvement occurred in both placebo and AHCC receiving groups, 92 percent of the AHCC group had recovered to typical pulmonary structural characteristics.

Information. “AHCC.” Teikyo Medical Journal. Volume 44. Issue Number 3.

It is important to know that lists or stacks of versions of viral, oncology, impairment, disease, genetic disorders and other factors, voluminous lists, are presented in the literature as being benefited or abrogated, as well as having abrogated symptoms from these factors.

These include conditions such as Parkinson’s disease also. Again, the analysis is only at item 4 or item 6 or 7 of 130. The analysis has briefly endeavored to go wide in ascertaining the breadth of these 6 or 7 factors to understand if the list can really be 10 instead of 130. Although each such analysis potentially reveals that another underconsidered factor should be promoted to be among the list of detrimental factors.

The manner of clinical study, clinical work, and therapeutic analysis, as well as care required to produce such studies and information is remarkable and a credit to those able to produce such arduous analysis, tasks, and outcomes information

Importantly, there are pervasive homologous to this data in human outcomes and outcomes among systems, even those outcomes which are considered to be detrimental and including those outcomes which are considered to be optimal. Although vital being and optimal human outcomes however possible, not merely however practical, should and are always system priorities, these demonstrate that systems may often be analyzed or scrutinized according some of the somewhat impossible assure practical objectives or popular ideas of utility for such systems. These analyses suggest that true objective of systems may be to work together to produce the observations, information, and understanding that allows analysis, critical thinking, discoveries and ways of improving human outcomes to occur. These big objectives in which humanity moves forward toward transcendence seem to be obscured by the focusing events that occur at geopolitical, political, national, regional or other levels. Such that humanity might improve the condition of humans and the effectiveness of systems in assuring Human outcomes, there must be a status quo from which such improvement or transcendence might occur.

Clearly, management or inhibition of homocysteine, s adenosyl homocysteine, AP1, SP1, iNOS, uncouple NOS and Cholilne Kinase, using Active Hexose Correlated Compound as well as therapeutics, supplements, neutraceuticals or other mechanisms of managing these may eradicate HPV, destabilize or eradicate HIV, may be prevent or eradicate pervasive other viral conditions, parasites fungal conditions, microbial or bacterial affliction, an expansive group of oncology versions that even includes voluminous oncology conditions that are not linked to microbial affliction.

This discussion thread includes some discussion of viral vectors for disease, including those potentiating oncology. A relevant context is presented here.

Folate receptors are upregulated by elevated homocysteine, and are a feature of pathogenic oncology and can occur in typical cellular entities. Folate receptor synthesis upregulation can occur in pathogenic conditions although in some oncology, such as cervical oncology, such upregulation is not regressed once folate adequacy is achieved. Such folate receptor upregulation occurs without required upregulation of folate receptor mRNA or upregulation or an increase in hnRNP E1. Homocysteine upregulation was coordinated with Folate Receptor upregulation. Folate receptor inhibition may be therapeutic in cervical or other oncology to counteract persistently upregulated and overly persistent Folate Receptors. Impaired ubiquitinase activity, modulated proteolysis as well as changed autophagy may also explain overly persistent folate receptor activity. J Clin Invest. Volume 113. Number 2. Pages 285 to 301. Jan, 2004. PMID 14722620.

The literature presents that In Vivo delivery of CRISPR/CAS9 focused on excision of HPV E6 and E7 genetic structures using pegylated liposomes results in complete regression and disappearance of neoplasms and results in 100 percent survival of experimental study participants or subjects.  The gene editing was largely linked to NHEJ compared to high fidelity homologous repair, but this could be a result of large gene editing payload, although the neoplasms disappeared through apoptosis suggesting that cellular and humoral immunity as well as cellular decision mechanisms were extremely efficient at removing neoplasm or oncology once HPV E6 and HPV E7 genetic sequences were excised. Protein transduction therapy is field that has emerged and mature in developing protein domains that enable large payload biologically active molecules to be moved into the intracellular environment where intracellular chaperones reshape the payload into biologically active quaternary structure to resume shape, twist, writhe and reactivity characteristics. Linking CRISPR/CAS9 to transduction domains should allow the removal and deactivation of every known pathogen from human biology and should be able to cause the disappearance of every known oncology by excising or repairing the required genetic factors, typically numbering more than 1000, in oncology. Protein transduction domains enable large molecules to permeate cellular physiology with 100 percent coverage and the efficiency of a water molecule’s permeability of cellular physiology.  Information. Mol Ther. Volume 27. Number 12. Pages 2091 to 2099.  December 4, 2019. PMID 31537455.  Information. Gene Therapy. Volume 8. Numbers 1, 2, 3 and 4. 2001. March, 2001. 

CRISPR/CAS9 has already completed eradicated HIV in small nonhuman mammals in 2013. Information. Nature Communications. Volume 10. Article 2753. 2019.

A most important observation in this context seems to be that in the context of translation wellness achieve by translational medicine, CRISPR/CAS9 along with protein transduction domains, potentiates rapid translation or reducing of discoveries and insight in biology and therapies, as well as disease and regenerative medicine into practice using personalized groups of interventions.   Simply, not only is it possible to devise a combination therapeutic or groups of therapeutics for an individual, but using proteomic decision which CRISPR has already demonstrated, each cellular entity in physiology can have an individual care plan.  

This data is presented in one of the wellness artifacts at translationalwellness.com

continuing research and develop is occurring at translationalwellness.com. There, they are translating this information into usability competent tools, technologies and empirical conclusions as well as guidance for providers, practitioners, patients, systems and industry or other organizations.

Clearly, there is something inadequate presented here. These represent some among many ways in which any system of the universe, or any system of civilization, has the inherent propensity to prioritize itself over its incipient purpose, incipient utility and over humanity.

These all present the manner in which workers in systems prevent systems from annihilating humanity and abrogating species. Every day the humanity continues to exist in context in systems result in consistent selection of the most detrimental alternatives and imposition of unnecessary massive detrimental outcomes among humanity 
represents the service that workers in systems of civilization and workers providing service in civilization all have triumphed. Its victory that must be achieved every day. Its indication that less-than-optimal outcomes or detrimental outcomes among system workers and humans do not indicate human flaws but represent instances in which systems
have broken through the protection that people in systems provide from the inherent nature of systems to prioritize themselves over humanity. 

Consider this. Ask any individual or group representing humanity the following.

If every wireless service provider contract allowing providing of wireless communications inhibits PEMT, causes iNOS, phospholipase D, phosphatidylcholine specific phospholipase C, also in the lumen, also in alveolar lumina, causes freakish biological occurrences in the lumina, is integral to massive detrimental behavior, disease and abated being, then why are these allowed to exist or occur and what must workers in systems to do counteract these?  

If changes in electricity output since the 1800s inform in near perfect correlation the change in abated vital being since then, why are these allowed to occur when they can be mitigated by insulating and shielding all electricity and communications wiring or interfaces in homes, dwellings, buildings, open areas, infrastructure, devices substations as well as power generation stations while also what must workers in systems be required to do counteract these effects.

Since it is known that homocysteine and PEMT are the core of disease and causes deterioration of social function, then why do we allow these to escape being priorities in care and escape being acknowledged as priorities in deliberations regarding detrimental outcomes as well as escape being priorities in synthesis of social constructs. Why are these allowed to cause massive detrimental behavior and what must workers in systems be doing to counteract these and prevent the complete deterioration of civilization?

Since it is known that implementation of abated vital being as a sanction causes between 20,000 and 1,000,000 or more instances of abated being on one civilization alone, with similar increase caused among the world’s population, with substantial increase in detriment to system workers, massive increase in transportation mishaps, decreased span of being, and other detriment, why is this imposition of abated being continued to be utilized as sanction? As many as 550,000,000 or more detrimental outcomes are linked to 1,000,000 instances of vital being if maintaining ratios of abated being to detrimental outcomes, such that 550,000,0000 instances of detrimental outcomes each year expands beyond the capacity of civilization and becomes causal to massive geopolitical conflict and detrimental outcomes among the world’s populations. What must system workers and the world be being required to do to counteract this massive detriment. 

These susceptibilities are known to harvest humans in susceptible contexts to produce massive detrimental outcomes. 

Since 1906, enough economic resources have been expended on temporary solutions that allow profit or benefit to be obtained from other’s misfortunate such that, instead, a home for each familial group could have been constructed and provided freely to them. Why not just begin building homes for those who require it and allowing people to pay as they are able at costs for those homes instead of continuing allow benefit to be obtained from human misfortune? What must system workers and the world’s population be being required to do to managed or counteract these conditions?

Permanent magnet solutions allow hundreds of thousands of megawatts of free, wasteless energy production. Why are civilizations continuously selecting sources of energy for homes, infrastructure, transportation, automotive, industry, and other applications that produces massive wastes, produce atmospheric and environmental particulate/pollution, are excessively expensive, produce waste that can be used to produce massively detrimental artifacts, and cause the most massive detriment to human populations.  

Why are water management solutions excluding the production of water freely from atmosphere and including doing so at the oceanic or aquatic boundaries with land to assure adequate moisture when producing water freely from atmosphere in quantities of billions of liters each day?  Why are the most detrimental, invasive, environmentally detrimental solutions to water management and obtainment being selected?  What must system workers and the world’s population be having to do to manage or counteract these detrimental selections?

Civilizations which do not provide adequate living wage freely to its populations that exceeds the requirements for housing, nutrition, water, health services, education, safety, stability, human condition, social condition, behavioral condition, physiological condition and the economic condition, amplify the effect of Roemer’s dynamics and cause global exhibition of Roemer’s dynamics in which human detrimental outcomes increase to satisfy the requirements of organizations and populations of the world providing services utilized to manage detrimental human outcomes. Why is a living wage not assured in such regard. What must system worker’s and Human populations be being required to do to counteract these dynamics

Thus, what is a capitalism, value synthesis in the foundational pathways of satisfying human, social, behavioral and physiological requirements or is it mere competitive grab for the modes of production and natural resources such that private interest can impose their biases, priorities and interest upon Huan population. 

Thus, what is Democracy? Is Democracy a system in which any Majority is allowed to impose its biases, inadequate understanding, inaccurate opinion, opinion, and priorities on any less than majoritarian group, including imposing these detrimental decisions and contexts on populations that can be scapegoated because they are not among a majority?  

What is a Republic? Is it the election of a system of laws a Ruler that operates with impunity, imposing social constructs and sanctions that result in millions of instances of abated being each year as well as 550 million detrimental outcomes each year, with similar effect to the world’s populations? Is it exclusion of biology and science from social construct synthesis and as well exclusion of these from being priorities in deliberations regarding detrimental outcomes in a way that requires humans to be acquiesce to being causal for detrimental outcomes, causing humans to believe that these outcomes emanate inherently from humanity while systems impose the conditions that deteriorate social function, neurology and foundational nuances of cognition while commandeering the cues for primitive complex resolution of these in nature in a way that assures systems that benefit from detrimental human outcomes are continuously utilized with objectives, quotas and revenue objectives that require detrimental human outcomes occur become assured?   

Or, could the Golden Apple of a Democratic Republic be a priority for Life, Liberty and Pursuit Happiness with systems of civilization and Constitutions performing as the silver frame for that Golden Apple, with capitalism a modality of assuring opportunity, assuring value creation, and most efficiently and most effectively keeping Democratic Republics true to the favor of the Universes afforded to each among Humanity?

The founders of modern civilization’s systems have not ever intended to produce a static, unchanging group of institutions as the core of a civilization. Modern civilizations were intended to continuously elute information about the human condition, requiring analysis and understanding, followed by ever improving synthesis of social constructs that improve the human condition, expand liberty, and prevent exhibition of detrimental nuances of the status quo. Imposing massive levels of abated being upon populations because one thinks that are privileged to do so, because one decides to ignore science and biology, or because one exhibits biases that can only be confirmed by imposing outcomes consistent with those biases, does not constitute processes consistent with a Republic or a Democracy. Similarly, imposing a system of social constructs and deliberations that excludes biology, excludes science, ignores data, ignores mechanistic links and is designed to reserve absolute priority to such a system of social constructs itself over humanity, human vital being, Liberty and opportunity, are wholly inconsistent with the Golden Apple, the Silver Frame, and with the favor afforded Humanity by the Universes.  

Even drugs pervasively increase homocysteine, iNOS or inhibit PEMT directly or competitively by competing for methyl groups. 
The function of PEMT in producing PMME, PDME, and phosphatidylcholine is important in the pandemic and epidemiological climate because it is populations that have strongest PEMT function and highest fraction of maintained PEMT function who are least susceptible to complications from the viral vector of the pandemic.  This is because iNOS expression is required by every virus, PEMT is inhibited correlative to age, homocysteine is increased typically in correlation to age, and phosphatidylethanolamine, PMME, PDME, and phosphatidylcholine enriched fraction all are linked to upregulated proteolysis and protein deterioration by trypsins, tissue plasminogen activators and xenobiotic response.   Viral proteins and structures are proteolyzed, autophagocytosed, or otherwise deteriorated by the PEMT competent physiology. The use of proteases and proteolysis factors such as nattokinase, serratiopeptidates, and other proteases such as NATTO and others, can be utilized to assist in deterioration of viral proteins. 
Since the year 1878 when dimethylthetin could have been used to manage PEMT and Homocysteine, almost every disease and detrimental outcomes could have been prevented, alleviated or benefited.  A study by a prominent health services provider found that in a population of 10,0000 in which homocysteine was below 6 or 7 micromoles per liter compared to a comparative slightly lower population in which the levels above 6 or 7 micromoles per liter were exhibited, over a period of 1 decade there was 1 to 500 comparative risk for abated being from any causality, such that those exhibiting 6 or 7 micromoles per liter or lower exhibited only 1 instance of abated being while those with a homocysteine level above 6 or 7 micromoles per liter exhibited 500 instances of abated being.   This suggest that by not managing homocysteine using dimethylthetin beginning in 1878, followed by the observation that no known person exhibiting vital being in 1878 now also exhibits vital being, a species for the first time in the span of the exhibition of the Universes consciously imposed the complete abrogation of all of its own species that by depriving such population of knowledge, innovation, development and care.  It is important to know that homocysteine at increased levels is linked to all disease, detrimental behavior, risk for sudden adverse health events, risk for becoming a victimizer, being victimized, incurring accidents, exhibiting behavioral health conditions, or any factor linked to abated vital being of any cause including being in a geopolitical conflict.
Thus, by inventing new ways of inhibiting PEMT, a global fog of impaired neurology, cognition and physiology was imposed upon the world that resulted in the tumultuous events of late 1800s, 1900s and 2000s. Dimethylthetin was not utilized in any of the pandemics or epidemiological events.  Today, there is no requirement by any civilization that the empirical cause of disease be treated or managed in health services intervention. Every practitioner, researcher, manufacturer, drug development or other factor in industries that produce toxins, managed care, produce drugs and produce research, all have a business function filters out any innovation or change that will prevent exhibition of massive abated being and massive levels of detrimental behavior. Abrogating a disease results in potential revenue decreases. Civilizations that don’t provide assured incomes to their populations, assured housing, assuring nutrition, free water, and free health services, health services that a required to treat and prevent the empirical causes of disease , as well as civilizations that allow populations to believe that individuals are causal to detrimental behavior when in fact it is these allowed deterioration of the nuances of social function and behavior along with allowed exhibition of susceptible conditions which are the true empirical causal factors for detrimental behavioral outcomes, represent civilizations that knowingly and systematically cultivate massive detrimental behavior and detrimental physiological outcomes often as a way imposing and cultivating bias, imposing and cultivating power over others, as well as produce massive levels of revenue.  
The use of abated being as a sanction was paused in 1972 until 1976, resulting in 20,000 per year decrease in abated vital being among on civilization’s population alone. The trend however presented a pattern toward a 100,000 decrease within 3 years and nearly 1,000,000 or more decrease in yearly levels of abated vital being within about 7 or 8 years. Using a ration of detrimental human outcomes not resulting in abated being compared to abated vital being, this translated to a decrease in detrimental humans outcomes of 550,000,000 by the time this 8th year was reached in which a projected annual decrease of 1,000,000 instances of abated vital being might have been achieved. During the pause of four years preventing use of abated being, detrimental acts involving systems workers decreased to levels exhibited in the 1950s. Mishaps in massive transportation decreased by 75 percent. New highest ever average span of being was reached during such a pause. Each instance of abated being imposed as a sanction can produce as much as 90 million dollars in revenue. 1976 presented a conclusion to the moratorium preventing utilization of abated vital being as a sanction, regardless of the massively beneficial effect it was having to human health and safety of system workers. Most importantly, at global population levels, the same beneficial effect to increased average span of being and decreased levels of abated vital being was observed as was observed at the national level within civilization imposing such a moratorium.
Relevantly, since the 1800s when electricity became implemented in civilizations, a massive change to epidemiological patterns occurred. These include a nearly perfectly inverse correlation between change in electricity and change abated vital being among developing and adult populations, along with a nearly perfectly positively correlation beginning in 2009 after changes produced by a 2005 communications and safety act. During the closing of an embassy and exit of diplomatic personnel in 2020 to 2021, a municipalities rates of abated being from the pandemic increased immediately before and immediately after the decommissioning of the diplomatic location, clearly indicating that communications and information exchange had caused the increased levels of abated being. 

The lumen is the innermost areas of physiology from layer perspective, is intended to be innermost protect open areas of epithelia. A most important role of having a physiology or an anatomy is to protect the lumen from environmental detriment, including gestational circumstance which protects the emerging physiology from such detriment.  Pulmonary environment exhibits alveoli and alveolar lumina are areas within alveoli that physiology is intended to protect from environmental detriment.  Wireless, electricity, communications and atmospheric particulate, environmental particulate, all contribute to expression of iNOS, phospholipase D, and phosphatidylcholine specific phospholipase D which deteriorates the primary surfactant DPPC which exhibits phosphatidylcholine lead groups as well as depletes the primary membrane phospholipid phosphatidylcholine. 
Every virus requires iNOS and escapes the toxic plasma membrane interstitial space in endosomes produced by iNOS, phospholipase D and phosphatidylcholine specific phospholipase C activity. Bacterial lipopolysaccharide causes expression of iNOS. Inhibition of PEMT causes expression of iNOS because P53 expression with inhibited PEMT causes massive apoptosis in way that requires increase in turgor of intracellular environments in order to counteract massive decreases in the number of cellular entities per micrometer of tissue. Many therapies causes expression of iNOS.  Gravity changes or returning to earth from space causes iNOS to increase the turgor of cellular entities as a way to strengthening physiology to carry its anatomical mass. Many well-known viral vectors required iNOS expression and uncoupling of iNOS I which iNOS produces reactive oxygen species superoxide, H2O2, peroxynitrite, hypochlorite, and the cause of stroke and most pervasive cause of sudden adverse health events, complications and perioperative complications known as trimethylamine-n-oxide. Trimethylamine-n-oxide is also caused by eating meat, chicken, eggs, fish, choline dense foods, carnitine dense foods, all without a pre/post/probiotic or without a broad-spectrum antibiotic including without 33 DMB, grapeseed or fruity polyphenol exhibiting olive oil.   
The pandemic has revealed that wireless and electricity fields of any nature, as well as artificial light and atmospheric particulate, all are producing constant detriment to the lumina in diverse areas of physiology including pulmonary, brain, neurological tissues and other areas. It is now known that in a process known as decellularization, cardiac, pulmonary and other organs can be removed from physiology and have all cellular entities washed from extracellular matrix, followed by reseeding with stem cellular entities to enable regeneration of organs. The regeneration of organs completes outside of physiology and spontaneously resumption of biological rhythms completes spontaneously outside of physiology. The spontaneous regeneration and spontaneous rhythms are impaired or diminished when the organs have not been removed because of inflammation factors, including iNOS, which inhibit the function of PEMT and because inadequate ornithine is exhibited along with impaired extracellular matrix, laminin, Agrin, Hyaluronan, Collagen, as well as inadequate prevention or clearing of Progerin.  These are all integral factors in the causing of aging, cause of rapid aging, and are inadequately considered factors in every disease.
The factors that cause iNOS, inhibit PEMT and which cause homocysteine, all accumulate, such the already existing conditions, disease or susceptibility typically indicated increased levels of these and explain increased risk in particular groups, with particular disease, or with other factors.  However, since 1880 when first electricity substations were placed into areas of the largest cities, followed by atmospheric pollution and wireless communications, particularly including electricity infrastructure that is unshielded although all electrical wiring in any area, building or substation can easily be shielded or enclosed, but are not typically shield or enclosed. Electrical plugins can be covered, communications plugins can be covered, lights can be shielded, wireless networks can be replaced with wired networking, devices can be shielded, but again these are not typically done.
Accumulation of inflammatory cytokines, choline deficiency, inhibition of PEMT, homocysteine, diminished integration of CH3 into phospholipids, bacterial exposure, viral exposure, all accumulate and explain differences in outcomes. The care setting omits protecting brain, lungs, lumina and alveolar lumina from exposure to these factors.  An anecdotal example provides context. A patient presenting symptoms of upper respiratory illness instrument water diluted dimethylsulfuoxide in mouthwash, surface cleaning, as well as on a wet towel placed under the door of room and in window to allow fresh cleaned air to flow in room. Systematic turning off of internet sites, social networking, changing of addresses, changing of time zones on phones and computers, turning of communications protocols on phones and computer, configuring firewalls to specific allow only essential communications on phone and computers, resulting in continuous alleviation of symptoms lasting a few hours until symptoms resumed, followed by selection of additional internet sites and sources of iNOS. Covering power outlets, turning of television at night, all produce continuous improvement.  Periodic coughing symptoms were alleviated once it was realized electrical, wireless and electromagnetic fields were activating neurological pathways for coughing in brain, causing swelling of endothelium in physiology generally, and causing inflammation of lumina, including inflammation of alveolar lumina. A review of the literature demonstrated that transient alveolar changes can be affected by electromagnetic fields, such that the literature presents freakish ameliorated development of structures and lattices in the lumina attributed to grossly ameliorated status produced by electromagnetic fields, changes to quantum nuances of gravity, iNOS expression, inhibition of PEMT, homocysteine, phospholipase d and phosphatidylcholine specific phospholipase C.  
Unfortunately, internet sites in some civilizations derive their valuation from volume of users. Such sites sometimes remove the ability to delete accounts and refuse to delete accounts, as well as merely deactivated but do not delete accounts. A person trying to maintain their vital being may be thwarted and experience abated being as a result. Some civilizations have implemented GDP data protection act standards that protect individuals while other have not. Some social networks and sites have massive levels of accounts of those having experienced abated being, some of which have occurred because of the participation in the website or because the ability delete the account has been removed.  

Populations living pay period to period.  Populations without stability and safety.  All become susceptibility for harvesting to continuously fill places that managed detrimental behavioral and detrimental physiological outcomes.  
Roemer’s axiom is a phenomenon in which construction of new healthcare facilities in an existing service area results in an increase in demand until the new facilities are filled at similar levels as the existing facilities in the service area. The phenomenon is confirmed by social constructs, Certificates of Need requirements for Hill Burton Act Provisions in which public funding for health services facilities requires a certificate of needs assessment .  The certificate of needs requirements confirms that there is existing demand in the service area to prevent construction of new facilities in a way that would cause increased demand, increased instances of abated vital being and increase in detrimental outcomes. Massive hospital construction occurred outside of the Hill Burton Act provisions through private interests, resulting in a massive expansion in detrimental behavior, disease, epidemiological patterns, and consumerism. Consumer behavior is a known factor in susceptibilities introduced by homocysteine enabled subjectiveness, such that 90 percent of consumer behavior is known to occur from less than conscious interaction between physiology and systems. Pharmaceutical organizations utilize 50% or more of resources to advertise because homocysteine enabled subjectivity produces a competition between sources of advertising, marketing and sales, as well as cultural factors, bias, and disparities, a way that direct susceptibilities toward detrimental behavior, disease, mishaps, aging, victimization, or becoming a victim.
The Hill Burton Act was activated in 1946.   Funding under the Hill Burton Act was discontinued in about 1998, in synchronization with the discovery and addition of choline to the list of require nutrients. Although the levels of choline recommended are grossly inadequate, such that scientific analysis suggests that between 4 and 7 micromoles per KG of anatomical mass are essential to human health. 
The 35 and 50 or more factors are mostly applicable to the viral vectors and conditions involved in modern pandemics. 
This information describes that disease and abated vital being occur because systems and populations are allowed to benefit from detrimental human outcomes and budgets, quotas, revenue objectives, margins, and objectives that in any way allow revenue, benefit or sustainment to be derived from any detrimental human outcome becomes causal to such outcome because no organization or system is able to prevent or abrogate such outcomes when it means that the organizational or system can no longer be sustained when such outcomes are prevented or alleviated. 
Since 1878, all known humans exhibiting vital being no longer exist, specifically because dimethylthetin was withheld and the enzymes that process dimethylthetin were used to produce drugs that were provided to humans instead of providing them dimetylthetin or managing homocysteine in other ways.  The resultant massive deterioration of social function and physiology resultant of omitting these priorities are responsible for massive detrimental behavior and massive instances of abated vital being.  The use of abated vital being as sanction obfuscates these allowed exhibition of detrimental outcomes and causes more than 550,000,000 detriment outcomes and 1,000,000 instances of abated vital being each year, while also causing detrimental outcomes among systems workers, massive increases in travel incidents, decrease span of vital being, and causing similar increases of detrimental outcomes among global populations.  The inflated cost structures involved in these contrived nuances of human detriment include choosing massively more detrimental and expensive ways of obtaining water and obtaining electricity which can be obtained freely using ‘free water from atmosphere and using permanent magnet solutions’ such as calnetix which produces such massively more efficient generation of free and wasteless electricity.    These describe a remarkable focus on obtaining massive levels of revenue by allowing and causing disease and detrimental behavior as well as choosing the most toxic and detrimental ways of producing electricity and managing water.  In each instance, these analysis present that disease should not exist anymore, homelessness should not exist, water should be freely available with simplicity and no detriment to environment, electricity should be free and with no detriment to environment, and detrimental behavior should be almost nonexistent., such that these only continue to occur because it generates massive levels revenue and is required when a civilization does not freely assure the factors that comprise the human, social, behavioral, physiological and economic condition. 

These are very important because a review of the cause of Sarcoidosis clearly observes that atmospheric pollution, dander, allergens, animal dander, mold, microbes, and other factors enhance inhibition of PEMT and the allergic response that produces homocysteine. Similarly, C7/Teflon/perfluorooctanoic acid, entered awareness through many decades of analysis, and it was found to cause increase in a number of inflammatory mechanisms presented here as inhibitors of PEMT and upregulators of Homocysteine. Perfluorooctanoic acid, for instance, was found to upregulate pulmonary macrophages which are primary causes of granulomas by 2,400 percent in one study. This toxic factor is found in pervasive consumer products. Another study and cinematographic production observed that perfluorooctanoic acid has been allowed into the environment and has contaminated more than 99 percent of the organisms on earth in at least some level. A Similar analysis observes that since 1878 when dimethylacetothetin was discovered and enabled management of homocysteine, toxins, causes of oncology, atmospheric pollution, communications/electrical fields have been introduced that have become the principal causal factors to pervasive disease regardless of consideration of dimethylacetothetin. 
The popular literature has again started to produce propaganda promoting that diseases are somehow natural and immitigable, while vital being, also, by such entities, is presented as being wanton, expendable, limited immitigably. Ignore those entities, ignore those assertions, and utilize the information here relegate that nonsense to aspects of the human experience which become increasingly eradicated from the ability to affect human populations.

It suddenly becomes clear why autocracies emerged in the world before formal democracies emerged. Democracies require technological innovation, because without such innovation, democracies as they now may be, risk enabling the abrogation of species.
 
Why? Two examples are clear. The discoverer of how to obtain plasma for storage and utilization, was excluded from utilizing the capability in particular settings, excluding from a principal national role in implementing such capability and even incurred abated vital being from not being able to fully utilize such capability when the discoverer required such capability. Similarly, a leader of a civilization, recently to this composition, with the namesake of the research journal in which an 1878 article presents how to use dimethylacetothetin to deplete homocysteine, was deprived of that capability at an advanced age. Dimethylaceothetin would have likely added many more decades or centuries to the duration of the vital being for such a leader. These events occurred among the most advanced Democracies. The conclusions are that Democracies was be continuously trained to prioritize Life. Imperfect Democracies have a propensity to be Majoritarian and thus find nuances of the population who can be excluded and attributed causality for all of the detrimental outcomes that are required for the status quo to persist. Democracies, however, do not have to be this way.
 
However, in an Autocracy, one thing is clear. At least 1 person, 1 group or an Aristocracy, is sure to be prioritized, compared to the deprioritization of all Humans that can occur in democracies. A democracy early in Human experience in which biomedical capabilities are excluded from being utilized even for leaders and an aristocracy, would have resulted in abrogation of species. Autocracies were might have been essential to the continuation of the Human experience in these early junctures, although it is clearly not suggested here that an autocracy is optimal in all manner of administration of the affairs of civilization and that autocracies have led to and even provisioned their own democracies in acknowledgement that Republics are optimally guided by the populations which comprise them. 
 
However, this presumes that the population guiding a Republic are informed and are able to discern opinion from truth, presuming that such truth is linked directly to empirical nuances of reason. Thus, while it is true that abated vital being occurs among populations, the empirical nuances of reason implore that humans functionally, if not cognitively, have an inherent priority in resisting the occurrence of such observed outcomes.  Although it seems plainly obvious that such priorities as Life, Liberty and Pursuit of Happiness exist in civilizations, outcomes clearly present that abated vital being is acculturated. Thus, when does such acculturation constitute assistance and even causality, compared to mere observation? Not managing PEMT pathways as priorities seem to constitute such assistance and seem to constitute causality.  
 
Although these analysis seem like hyperbole, such analysis are important in the existing sociopolitical contexts. There is a substantial risk that systems have emerged as being incapable of being attributed causality for pervasive Human outcomes that do not occur unless systems are exhibited. Thus, when detrimental outcomes occur, systems implement interventions that do not acknowledge the empirical causal factors, attributing causality of these to humans and ignoring the 12, 20 or 50 factors that have to be exhibited for detrimental outcomes to occur, including the factors that constitute deterioration of metabolic, molecular, physiological, perceptive and cognitive bases for social behavior. Pervasively, these nuances of physics, biology, and biology, are excluded from deliberations regarding outcomes, structure of sanctions, and even are excluded from priorities in care, resulting in cascading Human events that result an endless supply of detrimental Human outcomes. 
Thus, systems, implementing interventions, expose their workers to an endless supply of detrimental outcomes, associates, conditions that confirm biases, and scapegoating, while not managing these 12, 20 or 50 factors even for systems workers themselves.  The result is, that true, incipient, causal factors, and activating mechanisms that cause detrimental outcomes among populations and workers within systems alike, are omitted from ascertainment, acknowledgement and alleviation. Additionally, when facilities managing detrimental Human become inadequately supplied with unfortunate outcomes and Humans to attribute such causalities to, systems workers then become substrate for the sustainment of systems.

A most detrimental potentiality is that systems can implement social constructs and sanctions that are grossly inadequate, caused increased detrimental outcomes, producing generational and collateral detriment, then benefit from doing so. Similarly, by attributing causality of detrimental outcomes that occur as a result of less than empirical resolution of causal factors in such regard, then system workers can be scapegoated. Thus, systems can escape from having to acknowledge and improve the ways in which systems cause detrimental outcomes, escape inadequate training, produce grossly obfuscating concepts such as the presumption that ‘a lot of training is equal to effective or adequate training’, as well as sustain an unwillingness to acknowledge the 12, 20 and 50 factors which would pervasively alleviate or prevent detrimental outcomes. These context exhibit populations being divided and turned upon one another, somewhat assuring that cognitive permeation of the subterfuge might not ever occur. It’s a canonical silencing of the lambs and silencing of the doves, resulting in synthesis of new mechanisms for Humans to impart detriment to one another using systems without having to understanding or acknowledge any of the causal factors. Likewise, systems, in this way, no longer have to responsibly ascertain the suitability of workers for the roles in which they are place, merely scapegoating such workers when less than optimal outcomes occur.

If every human, in what is the most wealthy economy ever to have existed, has a salary that assures adequate sustainment of social, human, behavioral and physiological requirements, then, would there be a reason to have such intricate nuances of social constructs and sanctions? Were the framer’s of the Constitution intending to assure specific assurances that maintaining of detrimental artifacts specifically produced to cause detriment other humans even when these have become among the most detrimental vectors to Life, Liberty and Pursuit of Happiness?  Particular nuances of the existing sociopolitical context exist in substantial dissociation from the incipient nuances of reason, the favor of the Universe and even the intended presumptive foundational assurances of Life, Liberty and Pursuit of Happiness. Humans cannot responsibly dispense with control over Human Life, except in absolute assurance thereof. Outcomes otherwise, merely demonstrate inadequate capacity. Thus, if one becomes aware of inadequate perspectives or biases, how effective are systems are in enabling these to be acknowledged, managed or alleviated in their workers. Similarly, how effective is a civilization in assuring that people coming to understand such inadequacy might be sustained in satisfying social, Human, behavioral and physiological requirements.

How many people, for instance, participate in systems that have less than optimal influence or which they are not able to impose their own priority of Life, Liberty and Pursuit of Happiness when it exceeds that assured by such a system, whom are empowered to do so?  How many people producing, exporting, importing and distributing artifacts specifically produced to cause detriment to others might do otherwise if other opportunity or an assured reasonable stability achieving income were assured? 

Thus, all that is required is an absolute priority of systems or a lack of absolute priority for Human Life, Liberty and Pursuit of Happiness. Outcomes, then, can become considered only in their most proximate nuances of time, causality, context, circumstance and outcomes, ignoring all of the factors that were required to be their disjointly to these proximate nuances, in order for systems to be directed toward scapegoating virtually any nuance of the population which a majoritarian influence decides to utilize in such regard. 
Thus, a democracy, unless informed with understanding, acknowledgement and priority of considering the bases of biology, physiology, perception, cognition, behavior and how systems affect these, has a propensity to potentiate abrogation of species. It is perhaps institutions that readily present mercy and forgiveness, which are nuances of the truth that is causality that is 99 percent extrinsic to humans, along with those institutions of art, science and humanities that have invested in and present understanding of the arts, sciences, humanities, applied research and other essential capabilities, which prevent a Republic and a Democracy from abrogating itself and possibly causing abatement of the Human experience.  Certainly, a Democracy in distant ancient eras would have been dominated by inadequate understanding, resulting in potential for such civilizations to become abated. Somewhat inclusively, this very outcome has occurred among ancient civilizations.   

These dynamics explore, more intricately, the observed inherent propensity for any system of the Universe to prioritize itself over its incipient circumstance, incipient purpose, utility and over Humanity. Such that empirical resolution of detrimental outcomes, along with prevention, alleviation and acknowledgement of empirical and incipient causalities can become secondary to sustaining the system, often by not implementing empirical resolution to detrimental outcomes in a way the absolutely prioritizes Humanity. Attributing causality to humans for detrimental outcomes in this regard, seems to be a way for systems to merely persist, preserve and perpetuate the status quo. A social construct and a sanction, as well as an Axiom in contexts of research, all represent an artifact utilized to replace empirical understanding. Bias also seems to perform in similar capacity.

A practical example is a building’s hallway leading outside through a set of Doors, being exhibited in a populous path of exist from the building. Detrimental outcomes are presented as someone or something causing people leaving or entering the building to stumble, fall or even fall into one another. The status quo exhibits that people falling to the ground and people falling into one another attributed causality for such outcomes. The cause of the falling is not ever acknowledged in deliberations, care, sanctions or outcomes. Thus, when facilities benefiting economically, social, culturally, through quotas, occupancy levels, or in other ways become empty, the factors causing such falling can be increase directly by observing more doorways or can be increased indirectly through systems of mechanistic links, such as decreasing the price of meat, chicken, eggs or fish, and such as increase electricity or atmospheric particulate, and even by constructing more hospitals and facilities use to manage such outcomes, all can be implemented.  

Particularly, in some systems, there are specific exculpatory provisions preventing the bases of biology, behavior, and physics from being utilized to explain what is happening, causing Humanity to be turned upon itself, mitigating immunity in systems that is one of the only context in which these factors are being acknowledged, thus reducing Human outcomes to the lowest common denominator of impaired assurance of Life, Liberty and Pursuit of Happiness. 

The gating mechanisms are the inherent nature of systems, as well as the absence of an assured salary and level of sustenance in civilizations, because this produces a circumstance in which Humans in any organization and systems rely upon the outcomes intervened by, managed by or otherwise causing utilization of the services, products or factors produced by such system or organization. This is known as Roemer’s axiom, such that is it well known that building new Hospitals in a service area results in increase of detrimental outcomes until the new services are utilized at nearly the same level as was exhibited when only the first Hospital was exhibited. Thus, when global resources are used to produce health and wellness capabilities, then imported into civilizations founded upon presumptions of assured Life, Liberty and Pursuit of Happiness, the result is that the inherent ability of Humans to derive sustenance from the biome and the Universes becomes directed at deriving revenue from the utilization of those products and services. The 5 to 10 million instances of detrimental artifacts using projectiles that are imported into such a civilization along with the production of such artifacts in such a civilization, including the pathways of distributing these, transforms the Universes, the biome and civilizations to exhibit those outcomes that require the utilization, purchase or obtainment of such factors. 

Pervasively, there seems to be an unwillingness to read the small amount of research required to demonstrate these linkages conclusively. Roemer’s axiom has long been refuted then acquiesced to by researchers and analysts who gradually able to perceive these dynamic in all manner of systems and outcomes. The abated use of Hill – Burton Act Provisions for Certificates of Need regarding health resources along with the repeal of the executive order preventing usage of abated vital being as a sanction, each have tight synchronization to emergence of pandemic microbial vectors across civilization, which is the context in which abated vital being is decreased when Hill – Burton Provisions and moratoriums preventing usage of abated vital being as a sanction are in place.  
Thus, the continued ignoring of PEMT pathways in care in behavior, as well as the imposition of abated vital being as a sanction, along with overt exclusion of Roemer’s dynamics from being integrally included as mechanism of control for how systems affect population health and behavior, all have emerged as the most detrimental vectors to Human populations and stability of civilizations. These have become of potential despeciating potential, as the expanding influence of Humans to the universe through systems of civilization, instead of the only through the Unique interaction capabilities of human physiology and behavior, began to inform the Universes how civilizations and thus the species, prioritizes itself or prioritizes Humanity. Heretofore, the Universes inclusively know and acknowledge, through the favor afforded Humanity in its physiological and cognitive abilities, Humans as the culmination of the creative forces of the Universe. 

These present very clearly why Majoritarian Democracies within Republics could only be sustained in modernity. Eras before modernity exhibited substantial potential for abrogation of species since withholding only a few innovations in research, understanding and health in earlier eras may been a determinant in the sustainment of civilizations and sustainment of species. The current era exhibits that particular nuances of populations are scapegoated, exculpating consideration of the bases of physics, biology, and behavior. The current era exhibits the highest numbers of species which are becoming extinct.  The potential outcome is that the Universes being informed of a depriotization of Humanity might become integrated with the reality that Humans really are a minority among the Biome and the Universes, causing the kinds of realigning elections that hardly any social or political context seems to be able to adequately perceive.

The obvious conclusion here is that producing localized nuances of reason, dissociated from Human priorities, it is possible to produce an endless supply of detrimental outcomes that seem be reasonable using only the means as a way of analyzing the outcomes produced. Exclusion of PEMT pathways from care seems reasonable, because it enables sustained, recidivism in emergency care, disease and detrimental behavior that results increase revenue higher case mix ratio from higher DRG scores. Executives and providers who focus on PEMT exhibit lower recidivism and decreased revenue for fee for service revenue/payment schemes, risking replacement for those less aware or less willing to provide care at this level. Similarly, outcomes in which abated vital being occur are explained away with statistics, and are dissociated from presumptive priority of Life, Liberty and Pursuit of Happiness.

There can be to be enough opportunity with adequate pay civilization to focus on assuring optimal Human outcomes at physiological and behavioral levels without allowing any entity to obtain benefit, merit, revenue or profit resultant of detrimental Human outcomes or requiring detrimental Human outcomes.

make no mistake here. The world seems tumultuous now because since 1841 and 1871, the group of 12, 20 cytokines or conditions which are required for detrimental physiological and detrimental behavioral outcomes, have been excluded from focus, acknowledgment and management by systems of civilization. The 50 factors that interactively shape these 12, or 20 core factors into detrimental outcomes have been allowed to persist in civilizations around the world because they confirm the inaccurate, opiniated, and scientifically refuted as well as statistically refuted concepts and ideologies of the past. Populations are being systematically abrogated and this information shows exactly how it is occurring as well as exactly to alleviate and prevent these nuances of systems from continuing to cause detriment at population levels and from causing detriment to you and those whom you have an interest in assuring exhibit optimal outcomes.

Disease
Every disease requires the exhibition of inflammatory cytokines, 12 or more, and about 20 or more metabolic circumstances as required, essential, causal, correlated and mechanistic links to exhibition of the factors, conditions, behaviors and pathologies know as disease and detrimental behavior. This is well known and presented by the research and data from about every nation upon the Earth and organizations otherwise.

Genetics
Pervasively these cause, enhance or allow genetic anomaly to emerge as changes to metabolic phenotype, thereby causing or enhancing disease and detrimental behavior.

The molecular basis of disease
These cause the exhibition of four major conditions. inhibition of the antinflammatory antihistamine CDP Ethanolamine pathways supply of Phosphatidylethanolmine to the enzyme PEMT. PEMT integrates CH3, which has Hydride the energy that fuels stars, into membrane Phosphatidylethanolamine to produce antinflammatory, enriched, Phosphatidylcholine, thereby causes de novo synthesis of choline and causing enhanced levels of hydride, capacitant/battery function of membranes, and is essential to maintaining background physiological pH between 7.2 and 7.6. This 7.2 to 7.6 background pH is required for conscious cognitive function, awareness or contiguous exhibition of the energy field that is ones being and links ones being to the Universes. PEMT inhibition increases S-Adenosyl Homocysteine, which then becomes Homocysteine, Homocysteic Acid and Homocysteine Thiolactone, thereby promoting systemic dsybiosis and uncoupling of cellular entities from the inclination to participate in group or social function essential to exhibition of an anatomy, as well as promotes exhibition of the enzyme iNOS which potentiates uncoupling of all NOS including iNOS, nNOS and eNOS. Also Resultant of PEMT inhibition, upregulation of P53 and upregulation of Choline Kinase as the first enzyme in the inflammatory histamine(when upregulated) CDP Choline pathway occurs. These impair the physiological basis of social behavior at the cellular level, tissue level, organ level, systemically, in the brain, cognitively and behaviorally.

Inflammatory Cytokine Dysbiosis
Regardless of what factors occur in civilization, such as the nearly perfect quantitative correlation since the 1950s and qualitative correlation since the 1800s between both pollution, chlorine/fluorine in water supply, electricity and wireless communications, use of striate in table salt, these factors cause the most detriment by invoking or perturbation of these 12 or more and 20 or more core group of inflammatory cytokines. These core group of cytokines are shaped interactively into the all of the outcomes observed in civilization, enabled by 50 or more factors that are genetic, molecular, metabolic, systemic, cognitive, behavioral, organizational, systems or civilization level factors. However, these factors must become translated into these 12, 20 or 50 in order to cause the change of such influence into disease or detrimental Human outcomes.

The 12, 20, and 50 factors all interactively, result in increase in Homocysteine derivatives because the 12 and 20 or more factors are potent inhibitors of the enzyme PEMT, although some may also result in upregulation of Homocysteine directly or also cause dysbiosis directly.

Every virus requires the exhibition or manipulation of iNOS for pathology. Every bacteria causes iNOS through membrane Lipopolysaccharide. Choline deficiency causes iNOS because choline deficiency causes massive cellular deterioration in tissues and iNOS increases gaseous pressure in the cytoplasm and plasma membrane interstitial space. iNOS is caused by restraint or entrapment, or forced immobilization, impairing the natural way the influences from all across the universe and from other eras/epochs influence Human behavior and migration. iNOS is caused by wireless communications fields and attenuation from unshielded wired communication. These included wireless mobile devices, wireless home electronics, electronics and even appliances. iNOS is caused by unshielded nonEMF insulated electricity infrastructure, electricity plugins/outlets, conduit, wires, substations, electricity transformers, generators, electronics, etc. iNOS is caused by Chlorine and Fluorine in water. All of these can easily and should have easily been mitigated through shielding, covering, enclosing, mitigating, placing into harmonic multiplexed frequencies/wavelengths, planning, provision of protective shielding and clothing, as well as through building materials selection and implementation of grounded, shielded, insulated conduits, circuit boxes, fuse boxes, wires, plugins, powerstrips, substations, and other factors.

Aging
Aging and the detrimental factors or differential factors correlated with aging, including risk for accidents, dementia, disease and abated being, are 99.99999 resultant of choline deficiency, inhibition of PEMT, inflammatory cytokines, inflammatory cdp choline pathway upregulation, Homocysteine derivatives, uncoupling of iNOS, eNOS, nNOS, as well as factors linked to such uncoupling including reactive molecular species Superoxide, Hydrogen Peroxide, Peroxynitrite, and Hypochlorite which, along with ingestion of meat, chicken, eggs and fish without pro/pre/post Biotics or antibiotics, are potentiators of the number one cause of sudden adverse health events, abated being and detrimental behavior known as trimethylamine-n-oxide. The difference in average span of being between genders are known to be strongly correlated to the difference in average levels of Homocysteine between genders. Every disease can easily be searched for in research literature and the internet along with the word homocysteine or the inflammatory cytokines, revealing that these are implicated in every disease, behavioral health conditions and detrimental behavior.

The Gompertz sigmoid and Makeham Sigmoid, both, when integrated into one, describe statistical graphs of risk for abated being among populations including two curiosities at the beginning and end that are regarded as mysteries, all are perfectly described by Homocysteine levels and more perfectly described by metabolic nuances that effect the metabolic infrastructure the depletes, recycles and prevents increases in Homocysteine.

Therapeutics
A review of therapeutics demonstrated clearly that therapeutics and drugs, including those used in critical and emergency care, caused upregulation of Homocysteine and several single spaced pages describes the effect of Homocysteine as an integral and foundational causes of almost every detrimental factor in disease, impaired biological function, impaired cognition, abated consciousness and discontinuation of vital being. Some even directly cause iNOS.

A useful way to describe this is that Homocysteine increases correlative to age, but modern civilizations and therapeutics as well as wholistic and other capabilities, should be assuring average spans of being between 200 yrs or as being indefinite. However, the baseline levels of Homocysteine and other cytokines are being augmented by Electricity, Wireless Communication, environmental pollution, deficiency, chlorine/fluorine in water, potential of striates in table salt, choline inadequacy, eating meat/chicken/eggs/fish without pro/pre/post biotics or antibiotics, learning which causes double stranded DNA segmentation requiring increased levels of choline, as well as other factors such mineral/vitamin inadequacy and decrease in nutrients within foods.

Each disease increases the level of these cytokines to cause the pathologies linked to such disease. Covid as a disease increases cytokines such as iNOS, resulting in increased levels of these inflammatory cytokines, particularly the 12, 20 or 50 factors. The reason that those who are of increased age and those with other diseases exhibited increased risk, seems to clearly by that their levels of Homocysteine and cytokines were already higher than other populations with less risk. The reason that some of those afflicted by Covid exhibit diverse impairments and pathologies afterward, seems to be that there were underlying existing genetic, metabolic and physiological as well as environmental circumstances that were affecting them more as well as may now be affecting them more than others whom are not experiencing such complications. These factors have to be managed in every patient and every person before they become patients.

Testing of vaccines resulted in adverse or ineffective outcomes among those whom were aged or both aged and in care facilities for the aged. The literature clearly implicates that the reason are not known, but like all of such literature in which causalities are presented as unknown, this is not accurate. Aged exhibits the highest levels of Homocysteine and inflammatory cytokines, on average. Inhibited PEMT and Homocysteine levels, as well as iNOS and other inflammatory cytokines from electricity, wireless communications, chlorine/fluorine, atmospheric/environmental pollution, and striates in table salt, all cause deterioration of the Thymus, hepatic organ, Spleen, and other areas or functions are comprise central nuances of Adaptive, innate, humoral and cellular, as well as other nuances of immunology. These studies and conclusions regarding the vaccine don’t even include acknowledging the metabolic basis of Immunology.

The data and research here provides both high level and specific information about how these factors should have been managed since 1841 and 1878 at the latest. These also demonstrate that these factors are integral to every disease and are not being prioritized adequately, at least since 1878 or perhaps since 1841.

This internet site or portal provides information on how to manage these factors to manage aging, behavior, health and health statuses, including disease.

These clearly show that populations are being systematically caused to exhibit abated vital being and because there has not been found in any civilization a focus on these in care to this instance, although there may be some civilizations that do focus on these factors, this deprivation of Human and civil rights has been utilized to produce bias and cause the outcomes the confirm such bias to occur.

However, there is one civilization that founded its systems upon the Golden incipient nuance of reason known as Life, Liberty and Pursuit of Happiness, which require that the 12, 20 and 50 factors be managed, prevented and alleviated for all whom are among the nation, as well as enabling these benefits to flow among all of Humanity. Regardless of if one considers the founders, constructors and implementers of these imperatives as systems of civilization to be biased or not, it is clear from these three priorities that they either exhibited no such bias, aspired to transcend their own biases if they existed, or aspired to produce a civilization that, itself, was intended to transcend human susceptibility to bias or other impedance to the furtherance of the Human experience.

Not one person whom constructed such systems incipiently are known to exist and not one person whom participated in divergence of civilization’s priorities from these to produce the status quo is known to exist. Thus, there is only the opportunity to get systems back on track in furtherance of Life, Liberty and Pursuit of Happiness among all among the nation, as well as allowing these benefits to flow to Humanity inclusively.

Regardless of one is seeking behavioral, behavioral health, medical, clinical, performance, financial, economic, social system disposition, or other assistance, the 12, 20 and 50 or more factors essential in determining Human outcomes must be known, acknowledged and included in every Human service, assistance, systemic interaction, disposition, solution, social construct, decision or outcome. If one seeks assistance in any regard, it is important that any such provider of assistance understand these factors from the amehsi website, otherwise, any assistance or resolution is merely likely to cause massive collateral, generational, and ineffective effect that moves unempirically resolved factors into other systems or to other populations that merely also only confirm the biases of those producing or providing such assistance or resolution. It is important to advise every person, those whom they care for, those they know or those with whom one interacts, to actively find as many of the resources they utilize which understand and prioritize these 12, 20 and 50 or more factors. It is advisable for any such person and those with whom they are affiliated to find locations, systems, nations, regional entities, locations, providers and services to which which they may move as group in order to have to receive services prioritizing these 12, 20 and 50 factors. There is no reason why Human populations should allow the continued omitting of these 12, 20 and 50 or more factors from service, care, systems and other contexts, particularly when these are the most integrally determinant factor in massive levels of generational, collateral and unnecessary detrimental outcomes. Since the 1700s, regardless of improvements in knowledge, capabilities and understanding, systems of nations have been unsatisfactory in translating the knowledge that was integrated into emblems and systems which clearly present innumerable references to PEMT pathways.

The pandemic of 2020 has clearly exhibited this inadequate Human priority, such that if the community you are in is not enclosing all electricity lines, substations, wiring, outlets/interface in homes, as well as removing the the increase in iNOS and other inflammation from 5G and wireless infrastructure from their effect to Human behavior and physiology, then how can it be possible to for any such context to have Human priority. Changes in electricity production is nearly perfectly correlated with changes rates of abated vital being since 1950 and since 2009, such changes are nearly perfectly positively correlated with changes in rates of abated vital being, while even early developmental population risk is also similarly correlated in these contexts. If such an obvious affront to Human priority, vital being, health and behavior since 1950 is not enough cause discernible and measurable changes to protect Humans, then what does this imply about systems generally? Certainly, Humans in systems have been integral in preventing systems from completely deprioritizing Humanity. When will systems be required to exhibit absolute Human priority. When will assurance of Human vital being, liberty and pursuit of Happiness, the Golden Apple of the Declaration of Independence, be reaffirmed as the priority for the Silver Frame or tools, systems and Constitution which implement the this founding Golden priorities?