Acetylcholine/Choline Deficiency in Chronic Illness – The Hunt for the Missing Egg

ucm278430We hear a lot about vitamins and minerals such as B12, folate, magnesium, vitamin C, and so on, but there seems very little talk these days on the importance of dietary lecithin and choline. Are you consuming an adequate amount of acetylcholine, or other phospholipids? The odds are that you are not.

A little bit about choline

The human body produces choline by methylation of phosphatidylethanolamine (from dietary sources such as lecithin and others) to form phosphatidylcholine in the liver by the PEMT enzyme. Phosphatidylcholine may also be consumed in the diet or by supplementation. Choline is oxidized to betaine which acts as an important methyl donor and osmolyte.

For those wanting to see how this relates to the methylation cycle, below is a nice graphic (courtesy of Wikipedia).

Choline metabolism

It is well known that magnesium deficiency is widespread (57% of the population does not meet the U.S. RDA according to the USDA), but the numbers for choline deficiency are even more shocking.

According the National Health and Nutrition Examination Survey (NHANES) in 2003-2004, only about 10% of the population have an adequate intake of choline. This means about 90% of the population consumes a diet deficient in choline. Furthermore, those without an adequate intake of choline may not have symptoms.

Along with folate and B12 deficiency, inadequate consumption of choline can lead to high homocysteine and all the risks associated with hyperhomocysteinaemia, such as cardiovascular disease, neuropsychiatric illness (Alzheimer’s disease, schizophrenia) and osteoporosis. Inadequate choline intake can also lead to fatty liver or non-alcoholic fatty liver disease (NAFLD).

The most common symptoms of choline deficiency are fatty liver and/or hemorrhagic kidney necrosis. Consuming choline rich foods usually relieve these deficiency symptoms. Diagnosing fatty liver isn’t as simple as running  ALT and AST since nearly 80% of people with fatty liver have normal levels of these enzymes according to a population study published in the journal Hepatology. In fact, in an experiment, 10 women were fed a diet low in choline. Nine developed fatty liver and only one had elevated liver enzymes.

For those who are genotyped by 23andMe, there is a SNP (rs7946) related to NAFLD you can look at in the PEMT gene called PEMT G523A (V175M). Caucasians with nonalcoholic fatty liver are more likely to carry the rs7946 (T), with the effect being most pronounced for rs7946(T;T) genotypes. [PMID 16051693]

If you are genotyped by 23andMe, make sure you are logged in to 23andMe and you will see your results for this SNP.

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Choline, the nervous system, and the heart

Despite it’s role in the CNS and stimulating parasympathetic activity, there is very little info about choline and mental illness. However, in a large population-based study published in The American Journal of Clinical Nutrition, people with higher blood levels of choline had lower levels of anxiety – however, levels of choline did not correlate with depressive symptoms.

Despite the lack of studies, it has been clinically observed that supplementing Lecithin or putting patients on a Lecithin rich diet can lower levels of anxiety, help the nervous system by establishing balance between sympathetic and parasympathetic, and even manage cardiac dysrhthmias. The Milner Acetylcholine Protocol (MAP) uses lecithin to manage cardiac dysrhthmias.

Phospholipids and the cell membrane

The fundamental building blocks of all cell membranes are phospholipids. Lecithin consists of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, Phosphatidic acid, other minor phospholipids and glycolipids. About 50% of the mass of most cell membranes are composed of phospholipids. The plasma membranes of cells also contain glycolipids and cholesterol – which correspond to about 40% of the total lipid molecules. Adequate intake of phospholipids and glycolipids is important for the integrity of the cell membranes. Lecithin contains a balanced amount of phospholipids and glycolipids.

Phospholipid supplementation has also been shown to help with mitochondrial dysfunction in patients with diseases such as Chronic Fatigue Syndrome, chronic Lyme Disease, Fibromyalgia, and Gulf War Illness. Fatigue reduced about 40% in Chronic Fatigue Syndrome patients after lipid replacement therapy (supplementing phospholipids) according to the Journal of Chronic Fatigue Syndrome.

Adequate intake of choline and choline-rich foods

Adequate intake of choline varies by age. Here is a table by CholineInfo.org.

Adequate Intake (AI) levels for choline are:

Population

Adequate Intake (AI)
of Choline

Infants:(0-6 months)
(7-12 months)
125 milligrams
150 milligrams
Children:(1-3 years)
(4-8 years)
(9-13 years)
200 milligrams
250 milligrams
375 milligrams
Adolescents:(14-18 years) 400 milligrams (Females)
550 milligrams (Males)
Adults:(19 and older) 425 milligrams (Females)
550 milligrams (Males)
Pregnant women 450 milligrams
Breastfeeding women 550 milligrams

CholineInfo.org also has a very nice graphic showing the best sources of choline. According to their chart, beef liver and egg are by far the best sources for lecithin with modest amounts in lean beef, chicken breast, cod, wheat germ, and cauliflower.
cholne-chart
Unfortunately, not all nutrition data is the same, and for the sake of comparison, below is what Wikipedia lists as high choline foods.

Animal and plant foods Choline (mg) Calories
32 gram sunflower lecithin syrup 544 250
5 ounces (142 g) raw beef liver 473 192
15 gram soy lecithin granules 450 120
A cup of wheat germ 202 432
Half a pound (227 g) cod fish 190 238
A pound (454 grams) of broccoli 182 158
A pound (454 grams) of cauliflower 177 104
Quart of milk, 1% fat 173 410
Half a pound of chicken 150 543
Two cups (0.47 liters) firm tofu 142 353 
A cup of uncooked amaranth 135 716
30 gram Brewer’s yeast (2 tbsps) 120 116
A cup of uncooked quinoa 119 626
100 grams of Soybeans dry 116 268
Large hardboiled egg 113 78
A pound of spinach 113 154
Two cups of cooked kidney beans 108 450
A cup (146 g) of peanuts 77 828
A cup (143 g) of almonds 74 822
Three cups (710 cc) cooked brown rice 54 649
A grapefruit 19 103

Since cooking eggs at high temperatures destroys the choline content, it’s best to cook the egg so the yolk is runny to preserve lecithin content. For people without egg allergies, properly cooked eggs is one of the best sources of lecithin.

In presence of an egg allergy, consuming liver or supplementing with sunflower lecithin may be the best options to ensure an adequate intake of choline. Sunflower lecithin may be a better source for lecithin than soy because unlike soy lecithin, sunflower lecithin is never derived from GMO crops. Also, soy is generally more allergenic than sunflower, so soy lecithin could potentially provoke unwanted effects in sensitive individuals.

Acetylcholine, phospholipids, autoantibodies, and a word of caution

Acetylcholine and antiphospholipid autoantibodies are seen in various autoimmune and chronic illnesses. It is well know that with Myasthenia Gravis, patients most commonly have autoantibodies against nicotinic acetylcholine receptor (nAChR). A large number of CFS patients may have acetylcholine receptor antibodies according to a study published in the International Journal of Molecular Medicine.

Dysautonomia and POTS can also be associated with autoantibodies against acetylcholine receptors. Mayo medical laboratories has a very comprehensive Autoimmune Dysautonomia Evaluation lab test that tests for autoantibodies against acetylcholine receptors and much more.

Antiphospholipid Syndrome (or Hughes syndrome) is an autoimmune condition that can lead to hypercoagulation and blood clots. Conditions such as Lupus, Sjogren’s syndrome, Chronic Fatigue Syndrome, and Fibromyalgia are often associated with antiphospholipid antibodies. Antiphospholipid antibodies can even develop in presence of chronic infections such as Hepatitis C, Syphilis, Chlamydia pneumoniae, EBV, HHV-6, Lyme disease, mycoplasma, Q Fever, and many other infections. Antiphospholipid syndrome can be tested for with LabCorp’s Thrombotic Risk Profile.

At this time there is insufficient evidence to determine if supplementing lecithin would be beneficial or harmful for those with acetylcholine receptor autoantibodies or antiphospholipid syndrome. More clinical research is needed to understand how lecithin supplementation influences the various autoimmune processes that may exist in these patients.

Whether you are a health expert with experience utilizing choline rich foods or lecithin supplements to treat chronic illness, or a patient using choline to promote your own health, please share your experience below.

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Regardless of what posterity may conclude regarding the pandemic of 2020, even if it is ascertained that rates of abated vital being were not increased during this period but merely moved into statistical categories associated with the pandemic as error, obfuscation or the natural dynamics of populations not having their essential requirements and the 12, 20 or 50 factors managed adequately, it is clear that not even a pandemic was able to require civilization to manage these factors, all of which would have been manageable since 1878. Importantly, not one Human who was alive in 1878 is known to be… Read more »

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It is important to know that inhibitors of Homocysteine and inhibitors of iNOS are known to inhibit the effects of the noxious gas utilized from 1939 to 1945, while also inhibiting the toxic factor which members of such regime utilized to abated their own vital being to avoid being captured having detrimental imparted by systemic processes. Thus, it is quite possible that these factors could have been utilize to fake the abated vital being of those whom were thought to have abated their own instances of vital being.

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If all the World’s participants in baseball only observed curves being thrown from pitchers and all the world participants in basketball only observed three point goals, then even if a fast ball were thrown or even if someone used a drop step, worked the low post, worked the high post, used pivots and the run step, these would only be consider in the context of the their curvature or in their relation to the three point goal. Thus, a world with literature dominated by the experience of less than optimal outcomes and abated vital being, is understandably shaped by the… Read more »

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Humanity shall persevere. Each one of you will be alright. As the song says, its gonna take alot of love, to make it this work. Its going to take people taking the time to understand why they do what they do. Its going to take every person in every system, as they do, protecting everyone else from the inherent propensities of systems and from the ways in which systemic interactions elute outcomes as behavior. Its going to take acknowledging that outcomes have ingredients and it will require comprehensive understanding that it is the act itself which determines competency because Humans… Read more »

fran
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If egg yolk needs to be “runny,” why is a hard boiled egg listed as a source

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the popular literature suggests cooking eggs thoroughly for bacterial and microbial protection. However, the esoteric literature observes that cooking choline changes it to be something else. There is a study of particularly nonhuman mammals used as pets which showed that these animals were living multiple times longer sometimes when eating raw uncooked foods and raw uncooked choline, while a cohort using cooked food began to exhibit much of the disease which are considered to be Human. Also, it is well known that choline is best absorbed, most useful, and more likely to not accumulate along with Carnitine and other factors… Read more »

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The response should be clarified. Pervasively, the detrimental and optimal outcomes exhibited as Human outcomes and events, are the result of these unresolved gaps in assured Human adequacy that are nuances of the detrimental aspects of the status quo. These gaps are often obscured by circumstance, limited perspectives, and involvement of people in roles or interests which compete in the resolution of such outcomes or events. Unempirical thinking and resolution, similarly to how not acknowledging that Ice Cream has ingredients, fundamentally impairs the ability to resolve inadequate outcomes, such as not ordering Ice Cream from the Manufacturer and the Manufacturer… Read more »

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The world stood by while the purges in the post WWII era including usage of fluorine to impair the masses was conducted in the Hegemonic Competitor to the Western Democracies in that era. The world stood by during the systemic massive abrogation of specific populations in the 1939 to 1945 era. Because the systems of this Nation elute the most fundamental components of vital being and social behavior at organism and cellular levels, these may have eluted or caused to occur all of the detrimental events and regimes since 1878 or since its inception in synchronization with advances in Lipid… Read more »

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Humans seem to have been intended to exhibit indefinite span of vital being. Even abated vital being has been experimentally reconstituted using these factors, such that Betaine, Choline, Folate, Trimethylglycine, even without the more powerful factors in this group of capabilities, in the clinical research are correlated with “abated vital being status becoming replaced by the continued exhibition of Vital Being.” Enough information must be distributed through the internet in this regard to counteract the pervasive information that suggests otherwise. Information has the ability to shape outcomes and inaccurate, less than thoughtful, or interest motivated information suggesting that Human vital… Read more »

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About a year and three months ago I went on the AIP, full elimination of nightshades, grains, dairy, soy, and processed foods along with methylfolate roughly 400-1000 mcg, and about three months into the program I tried adding alpha gpc to address pemt heterozygous and Mthd1. I could not tolerate the side effects, terrible drowsiness, fatigue, digestive issues and even headaches. Fast forward to now and I decided to try alpha gpc again, same exact supplement, started off 300mg at last meal of the day. I’m definately noticing an improvement in everything, especially digestion, energy levels, and mental clarity. However,… Read more »

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The existing climate is difficult to make assertions in because information being distributed is based upon systemic medicine and studies that are broad, distributed, double blind studies that can include placebo control groups. Placebo based studies are unethical and are anathema to the Helsinki Declaration because giving patients a fake therapeutic when they have detrimental health statuses is unethical. Also, every human is different in habits, location, environment, lifestyle, genetics, epigenetics, eating habits, fluid obtainment, and in other ways. Large Double Blind, Multiple Arm Studies, often do not control for all of these factors. A cure for a disease would… Read more »

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The Practice of Medicine is focused more on individuals. Personalized Medicine is focused on the individual. Care Guidelines do not focus on individuals unless they component grouping individuals such as phenotyping viral load. Care Guidelines do not focus on any one individual adequately unless they are personalized by assaying the 12, 20 or 50 factors that in inhibit PEMT. These 12, 120 or 50 factors that inhibit PEMT enable Species specific care and enable care to be focused within the species level to mitigate factors and causalities that vary between individuals.

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the guidance document can be found at
https://youarehealthyes.wixsite.com/website

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Website has been changed

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Complimentary Therapy for Microbial, SARS, Corona and Influenza Affliction The pandemic of 2020 presents the requirement for focused Guerrilla Healthcare Teams deployed as special ops teams that focus on the empirical causes of disease and detrimental behavior, including the required empirical factors for any pandemic or epidemic level pathogen. The epidemic of 2020 emerged because health services capabilities pervasively do not focus on preventing and treating the empirical causes of disease and susceptibility, allowing these to progress to diverse and exponential other causal mechanisms because these favorable change admittance, case mix ratio, level of impairment in DRG classification, increase outlier… Read more »

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The Amehsi Website was deleted, preventing the rapid presentation of a response to the emerging epidemic of 2020 by reactivating the site or by producing a specific clinical recommendation. The language was also changed and as soon as the site can be translated to change the language, there will be a specific guidance provided there An interime guidance will be posted here, now in subsequent responses. It is important to know that the data here presented already shows how to prevent, abate, treat the viral vector responsible for this epidemic. However, it is important to know that the reason this… Read more »

Beth
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Thank you for this interesting article. When I take a Sunflower Lecithin capsule, I feel amazingly at ease. It’s very noticeable. I have a chronic migraine disorder and Lecithin allows me to bear it. I don’t get nervous or depressed about feeling under the weather all the time. However, Lecithin gives me bloating and sometimes severe stomach pain. Not diarrhea, just a feeling like trapped gas. It’s so painful. Is there anything I can do to counteract that? Because I have had to stop taking Lecithin, but really don’t want to not be able to have it, because it improves… Read more »

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The literature is interesting in this regard. It is well known that Lecithin is a mix of phoshatidylcholine, other cholines, and noncholine factors, or it the literature presents canonical lecithin differently than it presents Phosphatidylcholine, at least experimentally and clinically. Lecithin is the earliest name for Phosphatidylcholine and it was isolated 1862 by someone named Adolph, suggesting how numerous other factors in Lipid Chemistry and Lipid Biology came to define much of the events of the 1900s. The 1862 version of Lecithin was derived from Soy as may be the version utilized in this clinical context. Soy is plantae and… Read more »

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The patterns of complexity in systems in this regard are not relegated to Health Services. Climatologists also have models that are starting present climate change as being off the charts in a direction that requires that some attention is required. However, the models implemented in climatology are equally dissociated from empirical nuances of systemic function as they may be in Health Industry. Hardly any Big Data implementation would come up with Choline, Hydride, Folate, Methyl Groups and PEMT function, as well as even Homocysteine as being causal factors in detrimental Human outcomes. This is because such systems are designed to… Read more »

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The CO2 and the Co2 are meant to refer to CO2.

Rosy
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I have pbc hashis sjogrens and myasthenia gravis. Im post thymectomy and having problems periodically. I also have celiac. I have had malabsorption my whole life esp fat soluable vitamins. I benefit most by taking cheap fat burner vitamins instead of the recommended phospatidyl choline because obviously my liver/gi isnt breaking the fats down. Fish oil turns me yellow but I can take cod liver and buy a special formulation. The cheap fat burner vitamins contain choline, b6 and either green tea or vinegar. I dont know how the choline is formulated but it worked for me. Coffee is supposed… Read more »

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0 no info

Carla Owens
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I have mixed connective tissue disease/lupus along with POTS And tachycardia… I recently did a blood test for vitamin/mineral deficiencies and I was severely deficient in choline. In addition to adding choline should I be also adding lecithin? Trying to deal with my health conditions by addressing deficiencies. I would love any input.

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a

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Lupus is every disease, in that is not a disease at all, but a differential outcome caused by the same cascade of pathology which every other adverse outcome requires. Reviewing the information for lupus provides an important opportunity for learning. Therapeutics for disease often increase the causes of progressive deterioration of physiology, such as increasing levels of Homocysteine sometimes merely by competing for methyl resources or even requiring methyl resources to be cleared from physiology. That which alleviates a symptom of a disease could easily introduce numerous other factors that cause other diseases and decrease span of vital being as… Read more »

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Item 6 A, Homocysteine, should included Vitamin B6, Vitamin B12 Methylcobalamin, Adenosyl Cobalamin, Free Cobalamin, Folate, NAD+, and Molybdenum. Additional Info–> 6A and 6B represent what may be the strongest ways of managing Homocysteine. Hydride indequacy.–> Hydride supplement or Choline Supplement. (optional) 2. Supplemental Hydrogen.–>(Optional) 3. Methyl Group inadequacy.–>Choline Supplement. 4. Choline Inadequacy.–> 800 to 1326 mg of Choline supplement each day or 4 to 7 mg of choline per kg of anatomical mass each day. 5. Vascular Inflammation from striation factors in some table salt. –> Using only Ancient Pink Himalayan Sea Salt and not using typical Table Salt.… Read more »

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Choline has to be raw, uncooked Choline in order to stably count toward the daily requirement, with preference for Liquified versions because Cooked Choline is changed structurally and metabolically. Item 6 A, Homocysteine, should included Vitamin B6, Vitamin B12 Methylcobalamin, Adenosyl Cobalamin, Free Cobalamin, Folate, NAD+, and Molybdenum. Magnesium Citrite should be magnesium citrate Additional Info–> 6A and 6B represent what may be the strongest ways of managing Homocysteine. 1. Hydride indequacy.–> Hydride supplement or Choline Supplement. (optional) 2. Supplemental Hydrogen.–>(Optional) 3. Methyl Group inadequacy.–>Choline Supplement. 4. Choline Inadequacy.–> 800 to 1326 mg of raw uncooked preferably liquified Choline supplement… Read more »

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After an economy of scale has been realized, it is more than likely that a a combined or integrated altogether drink, intravenous capability, parenteral capability, powder, pill, capsule, tablet, topical or other capability, all could be produce. Each such application would eventually become producible for less than 1 dollar per application after automation, utilization of existing manufacturing and development capabilities, and utilization of existing infrastructure occurs. It is difficult to understand how 3 million instances of abated vital being which might occur each year is less important than other processes that seems to have captured the focus of the populace… Read more »

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its also important to know that the recommended levels of choline obtainment are not the levels required to alleviate any disease. Choline is deficient in pervasive aspects of Humanity and it is the primary cause of every disease because it results in decreased Hydride availability, decreased methyl group availability, decreased Phosphatidylcholine, inadequate enrichment of Phosphatidylcholine, impaired sterioidogenesis and impairs the ability of tissue/molecule integrated H- or Hydride in its mission to sustain alkaline pH in the ranges of 7.2 to 7.4 or 7.35 to 7.45 or the alkaline ph ranges required for conscious cognitive function. The Strong Ions when compared,… Read more »

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Using the Amehsi Website, you and your provider should be able to determine an effective therapeutic path for any health status.

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Thus, concludingly, the following can be presented. Human vital being is indefinitely sustainable, but requires synergy with civilization and the Biome, all with Human Priority, thereby enabling Human cognition and activity to focus on Human prioritization and development along pathways of function, thinking and behavior which continue apply Humanity, systems and the Biome to the favor of the Universes among which has come to be exhibited. The favor which made a place in the Universes, requisitely for Human exhibition, provides an important empirical nuance of reason, Vital Being, Human Human Vital Being, is the most empirical observational and empirically assured… Read more »

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Liberty, it seems, is interesting in this regard. For, as people of the Western World, and particularly Americans, the very structure of civilization and being, endeavors to further the development of intricate nuances of liberty, including being, without practicality, drawn to the locus and resolution of impedance to Life, Liberty and Pursuit of Happiness. Every act or outcome potentiated as manner of amplifying the existence of Human inadequacy, regardless of if such outcomes is beneficent or less than beneficent. It is not presented any claimed knowledge of what is required to be great, for the endeavors achieved by this researcher,… Read more »

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This seems to be the complexity of Liberty and indeed of vital being among cognitively developed Human beings. Liberty brings with it an understanding of those circumstances from which Liberty has been eluted, resulting in a sometimes impractical pragmatism. Liberty brings with it an more clear perspective of what comes next, making the endeavor of Liberty assurance and Liberty achievement an endless integral component of Human Ideals and functions. However, it is the exhibition of the endeavor to achieve objectives, goals and outcomes, which seem idealistic, without a clear mechanisms or path to success, such that its very tangible potential… Read more »

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It is easy to conclude that the information here with misspellings and extensive phrases, with numerous permutations of logic are less than structurally adequate. However, these are important in conditioning people to extend their reasoning to beyond cursory levels of observation to achieve consciously extended permutations of reasoning, such that one is able escalate cursory associations to conscious levels of consideration in which Human priorities and incipient nuances of reason are able to disrupt the way systems utilize cursory associations to produce outcomes which circumvent Human priority. Importantly, in civilizations in which the known causes of every adverse Human outcomes… Read more »

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Every instance in which a detrimental Human outcome is attributed to those who incur them, without acknowledging all the ways in which such outcome has been allowed or even caused to occur through Human inadequacy, potentiates that the Universes be turned upon systems or potentiates that the Universes be conditioned or taught to disfavor Humanity. Essentially, such factors clearly make dispensable the culminating nuances of the favor of the Universes. Pervasively, such outcomes merely demonstrate most clearly, required resolution of Human inadequacy. Observingly, the Universes were here before Humanity, the universes can be affronted with Humanity or be affronted in… Read more »

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Consider every genettic condition as a metabolic syndrome until you get between 4 and 7 mg of choline per kg of anatomical mass, 500 mg of s-methyl methionine using gastromendhp, nad+, 500 mg of methylsulfonylmethane, 300 mg of grapeseed extract, 500 mg of l-arginine, 500 mg of mixed rna/dna nucleotides, 500 mg of ribose, 1/4 tablespoon of pink himalayan sea salt, no typical table salt, only filtered water, amineral supplement including alkali minerals, zinc, molybdenum, all b vitamins with methyl cobalamin. 5678 methyltetrahydrofolate is the best filate to include. You also must cover up the power plugs and outlets in… Read more »

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Importantly, these analyses suggest that Subversion is a nuance of the detrimental aspects of the Status Quo. Subversion seems to emerge in civilizations when any Human is required to perform activities to obtain Human, Social, Behavioral or Physiological Requirements which counteract, subvert, circumvent, or surmount the practices, algorithms, routines, social constructs, opinion and decisions as they have cumulatively emerged in civilization. It does not seem to import if such subversion is result of bona fide impedance to Human Priority in such nuances, if such impedance to Human priority is the result of factional activity within systems or outside of systems… Read more »

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Understanding how this could be is somewhat uncomplicated to present. There is not reason why a conspiracy theory has to be presented. These outcomes are merely the resultant of analytical output known as derivatives that determine what organizations do, should do and should not do, along with a slope or graph of the effect of doing whatever it is that an organization does do or might do or might not do. Derivatives are use to represent at what temperatures, solution characteristics, other solutes, or other factors particular output of an eluting factor such as Thioglycolic Acid, Glycolic Acid, Thiozalidinones, or… Read more »

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Essentially, therapeutics being developed or utilized are not required to alleviate a condition, but can manage factors proximately causal, correlated to or required for condition. Every health status, again, is different in every individual. Thus, during studies, the most frequently exhibited response, including other outcomes or responses to a therapeutic, can become representative of the effects of the therapeutic, comparatively to understanding the reason why diversity in responses occur because large populations have such diverse genetic, lifestyle and environmental factors. During In Vitro studies, the factors emerging from and affecting Hydride, Choline, PEMT, and Homocysteine are not pervasively managed although… Read more »

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Fundamental Algorithms presented hear the challenge the status quo because instead of allowing Homocysteine, impaired PEMT, inadequate Hydride/Choline/Methyl Groups, all to flourish and produced diverse causal lineages to therapeutically susceptible pathology factors, these alorithms alternatively focus on preventing, alleviating and repairing the detriment of the full stack of pathology factors including those which are shared by every disease, every detrimental outcomes and those which are exhibited when all available therapies for a condition might have possibly already been implemented. Always work with your physician to peruses the therapeutic stack, adding therapies until conditions abate and detriment from adverse behavioral or… Read more »

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Managing Sudden Adverse Events (other strong Neuroprotectants and stabilizing factors as well as all requisite biomedical capabilities are presumed to be includes as possible) 1 Choline at 800 mg to 1326 mg per day or 4 mg per kg to 7 mg per kg per day. 2 Energy Protection Beginning at First Contact or Before First Contact during an Adverse Health Event or Adverse Behavioral Event 3 Phosphatidylcholine 4 Dimethyl Sulfide 5 Molybdenum 6 A Broad-Spectrum Antibiotic During an Emergent Health Status or Sudden adverse Health Event or other Sudden Adverse Outcome 7 3,3 Dimethyl-1-Butanol 8 Tetrahydrobiopterin along with Sapropterin… Read more »

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Insight into Viral Conditions, Intervention Example including those which cause detrimental physiology, sudden adverse health events, diseases and detrimental behavior 1 Provide EMF Protection Clothing and Sleepwear. Cover Electrical Outlets. Manage communications and technology device energy field with EMF stickers and coverings. Remove personal information from internet, information systems or even paper lists. Freeze Credit Reports. Change phone numbers and addresses if they are associated with previous detrimental health or behavioral outcomes. Keep wireless Fobs and Keyless Entry Devices wrapped in Faraday Enclosures or EMF protection material as well as far away from treatment areas or dwellings. 2 Disconnect any… Read more »

ursula caballero
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ursula caballero

Hi,
Thank you ALL for such vast information.
I have a gene mutation at the CHRNA 2, 4 and CHRNB2 receptors for acetycholine. It is an autosomal dominant transmission mutation which causes me Nocturnal Frontal Lobe seizures, and many other symptoms related to the vagus nerve.
I would like to try Alpha GPC and L Serine to help with the chronic insomnia. I’m a bit nervous adding something to my brain function, since i react differently to many supplements and medications.
Any thoughts?

Jwarrior77
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Jwarrior77

Hey have you tried the Alpha GPC yet? I’m curious to hear if it helps you. I believe I’m also dealing with similar problems.

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The reason that one supplements with Choline isn’t to obtain choline. Absorption of choline can be inefficient unless its liquid and then it might to readily absorbed, produced from cooked or processed sources that impair the characteristics of Choline, might be impaired from being absorbed by inflamed digestive pathway from Trimethylamine/TrimethylamineNOxide/TNF Alpha or other, as well as might be being impaired in transport across membranes at anatomical level as well as at the cellular level by competitive inhibition or epigenetic/genetic impairment of Choline Acceptors/Transporters. The reason choline is important are the CH3 Groups. Exogenous choline has Choline with CH3 and… Read more »

Thomas Thibault
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Thomas Thibault

This can’t be true because you would need to eat more than 6eggs everyday, or 800 Gr of meat or 1kg of vegetables.. For have the adequate amount. Wich would be probably more harmful than beneficial. The suggest amount are impossible to get with any normal diet.
I also doubt the amount of lecithin you would need, I found totally other numbers

Jason
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Jason

Does it strike anyone as amazing that the American diet is end loaded with Beef Chicken and Eggs and yet only 10% of the population has adequate choline intake? How is this possible?

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Guest
Researcher

Every Human has deficiency in obtainment, synthesis through PEMT, synthesis through excess Betaine processing the inverted Choline Oxidation Pathway, or transport of Choline. Every disease has primary component that includes a factor that inhibits, impairs, competes with or benefits from inherent impairing SNP of PEMT. 800 mg 1326 mg of Choline are required every day, or between 4 mg and 7 mg per kg of anatomical mass for developing Humans, in order to replace the use of Methyl Groups, PEMT metabolites, resultant increase in Homocysteine, all from Immunological, biosynthetic, Gene replication/repair, Transcription and synthesis of bile from MDM2 required for… Read more »

Researcher
Guest
Researcher
InterestedRsearcher
Guest

According to the empirical data and the Amehsi.com website, each of the health conditions on this web page, including Genetic Conditions, should be considered as deficiency until the primary deficient pathways causal to detrimental Human outcomes are beneficially managed. Review the Amehsi Specification at Amehsi.com The factors to manage are Choline is required at 4mg per KG of Anatomical Mass each day or betwen 800 and 1326 mg per day for Human Adults. The dosage for other organisms or developing Humans should use the mg/mass guideline. Homocysteine whould be managed to below 7 Micromoles per liter. (Dimetylacetothetin, S-methylmethionine, Trimethylglycine, Folate,… Read more »

teri
Guest
teri

I have hereditary alpha tryptasemia- extra tryptase genes. It lends to MCAS, Dysautonomia, and connective tissue issues. The drugs that help with the MCAS is ketotifen (a mast cell stabilizer)- which is a strong muscarinic receptor antagonist (so I have read) which would be a acetylcholine blocker. Trying to wrap my brain as to how this fits in. I was noticing more Dysautonomia symptoms of shallow breathing, etc, so trying to find alternatives to the ketotifen. Thank you so much for this study….

Research
Guest

Choline deficiency, Hydride Inaquacy, PEMT inhibition and Homocysteine independently enable, cause and exacerbate every nuance of this disease and every other disease

OrganisedPauper
Guest
OrganisedPauper

I have several genetic factors that collide. More than one that affect the synnthesis of choline, meaning I’m likely to be deficient, and one that lowers the production of phosphotydilecholine. But, I also have more than one genetic factor which means saturated fat increases obesity and type diabetes and other health problems. Most sources of choline seem to come with a dose of saturated fat. As I need more choline than most people, and possibly betaine I’m not sure what to do. I have found saturated fat makes me feel quite ill. I already have Bipolar, diabetes, Fibromyalgia and possibly… Read more »

Mathew Carnage
Guest
Mathew Carnage

Nice article and thank you for the information. I knew about choline deficiency from here: https://www.xcode.life/23andme-nutrition-raw-data-analysis I didn’t realise that it had so much underlying genetics to it.

DebKlausing
Guest

You need of a supplement with phosphatidylcholine that is not in a pill form so it does not have to be digestive through the distractive digestive system with minimal absorption and therefore minimal effects. Phosphatidylcholine should be in the form of a liposome in order to have a 90% absorption rate for full benefits of phosphatidylcholine via the Liposome technology. Microlife nutritionals was developed by Dr. Emek Blair and became available to purchased January 2017 dklausing.vasayo.com for more information.

Lilac
Guest
Lilac

Choline can also make people very depressed, because it can lead to excess of the neurotransmitter acetylcholine. That is known to cause depression, and new drugs are being developed that block excess acetylcholine in the brain. See for example the work of Yale researcher Marina Picciotti. The body uses dietary choline to make acetylcholine. On the genetic side, some persons have a mutation in the BCHE gene (rs 1799807), which leads to a shortage of the enzyme “Butyrylcholinesterace,” which breaks down acetylcholine as well as other chemicals with choline. Thus this enzyme may lead to having excess acetylcholine, and one… Read more »

racerbiker
Guest
racerbiker

Hello Lilac, I have the exact problems with excess of acetylcholine. Have found that reducing foods high in choline and lecithin help tremendously. Have you tried nutmeg or any other medications ? Thanks racerbiker.

researcher
Guest
researcher

Another perspective is offered here. Homocysteine, TrimethylamineNOxide and the 12, 20 or 50 factors that inhibit PEMT have been pervasively causally linked to behavioral health conditions, psychiatric conditions, detrimental behavior and other similar disorders. Managing these can be pervasively useful in behavioral health. Choline availability, supplementally, through betaine supplementation to enable inverted choline Oxidation pathway production of Choline, as well as PEMT protection that allows PEMT to produce Choline De Novo, results in increased availability of Methyl Groups. PEMT when function, particularly when NAD+ is at adequate levels, although functional PEMT also assures NAD+, enables suppression of P53. P53 suppression… Read more »

SOCS
Guest
SOCS

Hi. Great info. Thanks all. Wondering the specific test names or test #’s for Labcorp and others you’ve mentioned. It’s so easy to end up w/ the wrong test, they have so many!

Ngasha
Guest
Ngasha

I have Ulcerative Colitis, Fibromyalgia, Asperger’s & MDD. I am presently (3/2017) in a double-blind study for Protect-3 phosphatidylcholine granules from soy lecithin in the treatment of U.C. It’s going good, I think I have the real thing, much improved!

Marcia Lester
Guest
Marcia Lester

I have Myasthenia Gravis, Hashimoto’s thyroiditis, Sjogren’s, and my dysautonomia was finally diagnosed. My infertility was caused by endometriosis(autoimmune), and, an endometrial receptor cell defect. MG is also a receptor cell defect. My neurologist, informed me, that MG with dysautonomia wasn’t unusual. Having trouble swallowing food, doctors diagnosed me with achalasia, related to my MG. I, also have common variable immune deficiency syndrome. Following, a second bout of thrombophlebitis, I was tested for anti-phospholipid syndrome and everything came back normal. Doctors felt the thrombophlebitis was secondary to taking b.c. pills and hormones. My B12 levels became elevated after I took… Read more »

Research
Guest

Get curcumin, Berberine, S Methyl Methionine and Grape Seed Extract. Also cover up the power outlets in your dwellings with tape and purchase EMF protection blankets, curtains and stickers. Focus on making sure that PEMT is function, Sulfur is available, use molybdenum to manage the sulfur if the literature about sulfur toxicity makes you uncomfortable, Methylsulfonyl Methane is beneficial but its usually applied for conditions affecting bones and other conditions. phosphatidylcholine, zinc and 6s 5678 Tetrahydrofolate, and NAD+ as well as nucleotide supplements should put these conditions out of operation. Alway, work these through with your clinician.

Mary Anne
Guest
Mary Anne

What if you have Lyme and CBS mutation, too? Turmeric, NAC, glutathione, milk thistle, B6, alpha lipoid acid are all contraindicated. Would choline supplements be ok to take, since CBS pathway is before methylation pathway?

Glori
Guest
Glori

So what’s the answer??

Researcher
Guest
Researcher

Responses were submitted and there was unusual indicator saying that these were subject to moderation. The answers dont seem to be here

Researcher
Guest
Researcher

Responses were submitted and there was unusual indicator saying that these were subject to moderation. The answers don’t seem to be here. Summarized these presented emerging nuances of Genetics, so supplementing with Choline pathways, NAD+ and Nucleotides can change Genetic Status or Epigenetic Status. CBS is in the transsulfuration pathway which suggest that Homocysteine accumulation is likely to be the sulfur excess problem while inhibition of CBS suggests that production 0f Sulfides is actually being inhibited. Choline, and Danshen/Red Sage/ Salvia Miltiorrhiza’s Salvianolic Acid helps transsulfuraiton pathway depletion of Homocysteine. Also, all of the 12 factors exhibit for two that… Read more »

Researcher
Guest
Researcher

Also, the links provided in the posts here which are not being shown exhibit links to research to show that Lyme disease relies upon inhibition of the 12 factors, 20 factors or 50 indicators, including inhibition of PEMT in order to move from one species to another and such movement is unintended by resultant of systematic suppression of Human physiological capabilities by allowed inadequacy, deficiency, energy fields, communications fields, chlorine, fluorine, bacterial affliction, diseases, many drugs which upregulate Homocysteine and upregulate iNOS, as well as Choline deficiency in particular. There were compelling links in this regard.

researcher
Guest
researcher

The best way to describe what is happening is an emerging pattern, algorithm, premise, or theorem. Every system, correlative to duration of exhibition, has an increasing propensity to prioritize itself over its incipient circumstance, its incipient utility and over Humanity. Its a natural phenomenon in any systems, including how organisms develop to acquire self reliance and sustainment. A useful example is if you have a system of implementing biomedical capabilities, like a person ask to distribute food form their farm to community, the system is likely to eventually exhibit the preferences of the system or preferences of the person distributing… Read more »

researcher
Guest
researcher

An perspective on Genetics is relevant. There are emerging perspectives on genetics. Substantial aspects of Genetic anomaly are considered to be epigenetic, inherited anomaly that are the result of environmental influence, resultant of deficiency, include substitutions that are resultant of deficiency, anomaly caused by supression of Homologous Repair, or occur because the numerous modalities of DNA repair such as excision, Near perfect Homologous Repair, NonHomologous repair, replication and transcription. Essentially, a choline deficiency impairs the production of Nucleotides for RNA and DNA, causing PARS and PARP to signal persistently, depleting NAD+ and NADH, until enough DNA or RNA is recruited… Read more »

researcher
Guest
researcher

Again, to reiterate, Vaccines should be developed using protein sequences used by pathogens and pathology which cause upregulation of the 12, 20 and 50 factors that cause disease. It is not recommended that any aspect of the 12, 20 or 50 factors be used to develop vaccines unless these are of exogenous origination or unless these have been very extensively analyzed to understand if these might result autoimmunological, impaired function or pathogenic gain in function anomaly.

Jade Edward
Guest
Jade Edward
Alessa
Guest
Alessa

Thank you for this very informative article. I recently had stomach issues and stopped all my supplements. That was two weeks ago and now my symptoms are bad. I have Sjogren’s and Hashimoto’s and I am in a huge amount of pain, have dry eyes, sore throat, and neck feels like it needs a chiropractor every day. I restarted my fish oil supplement yesterday and will restart lecithin today. I didn’t realize how bad things could get without it. As a sidenote, I also have CFS, depression, anxiety, and am extra sensitive to pain. I carry MTHFR but not sure… Read more »

Margie
Guest
Margie

I have primary biliary cirrhosis, nafld, sjogrens , pulmonary fibrosis, hashimotos. Went into remission but developed myasthenia gravis and menieres anyway. Am on mestinon. It is positively affecting my fatty liver, the fat seems to be finally getting better. I have always done better on vitamins with more choline and was in l carnitine while I developed the mg. U believe choline and supporting vitamin supplementation could be an effective treatment for fatty liver. The mestinon also helps with mental clarity. Mestinon increases acetylcholine. Tramadol or a derivative I think will be important also in treating autoimmune diseases because of… Read more »

researcher
Guest
researcher

Choline supplementation is the canonical therapy for Fatty Liver in the research. It may not be the standard in practice though. Choline, disrupts the shared causal factors upon which medicines pervasively can rely. Your clinician may disagree until you show them the research and, it seems, your clinician may have systemically conditioned propensity to disagree with using choline because it disrupts the foundational scaffolding of disease and therapeutics. Be persistent. It may be as important as obtaining Choline to also obtain Homocysteine depleting factors such as S-methylmethionine sulfonium, Trimethylglycine, 6s 5678 Tetrahydrofolate, Dimethyl Sulfoxide, Methylsulfonyl Methane and NAD+. B12 Methylcobolamin… Read more »

Garry
Guest
Garry

The achr-ganglionic autoantibody was found in my blood several years ago. Is there any new news on choline supplementation if you have this condition?

David Clark
Guest
David Clark

I found the site: http://amehsi.org/. And all I have to say is, wow, what a lot of information to take in. I have been having strong symptoms along these lines for a few years (I am 51 now). I also now realize that I may have had milder symptoms since being a child (particularly chronic diarrhea and trouble swallowing certain foods). I have only in the last few days, however, realized that I may be dealing with one of the myasthenic syndromes probably congenital (I am aware of a couple others in my family who have died of symptoms similar… Read more »

steve
Guest
steve

What about Egg Lecithin?
I use the Capsules from Nature’s Plus

Tomm
Guest
Tomm

It has a lot to do with nicotinic acetylcholine receptors like alpha 7 NAchR. It is involved in inflammatory pathways more than you would think.

Even patents for treating chronic disease with AChEI natural drugs like galantamine exist – http://www.psoriasisdietplan.com/2014/08/patent-application-published-in-2006-describes-effective-treatment-for-many-chronic-diseases/

That’s why smoking may help lose weight, alleviate arthritis, improve cognition, etc… or do right the opposite.

Huperzine A, Galantamine, lecithin, DMAE, …. and B-vitamins due to their importance in making the acetylcholine like B1 – thiamine.

Chris
Guest
Chris

For those struggling with B12 deficiency, I recently heard about a new oral prescription alternative to the injections called Eligen B12. I recently read that it works even if you don’t have intrinsic factor (so even if you don’t have normal gut absorption). Apparently it came out a month or two ago. Has anyone heard of it or tried it??

Dan
Guest
Dan

“A Researcher”: The info you have provided (and provided and provided and provided) is OVERWHELMING, and impossible to wade through.

Please try and make it ‘user-friendly’ to the average reader.

Thank you.

Terry Lynch
Guest

Researcher, I am very grateful or your metabolic treatise! I will be studying your profound observations until my dying day(maybe not so fa of at my age of 67.)

research info
Guest
research info

revised. If you can get Dimethylthetin as a supplement, Dimethylsulfoxide, S-Methylmethionine Sulfonium, Trimethylglycine, Red Sage or Danshen, 6s 5678 tetrahydrofolate, B6, B12, Zinc, Molybdenum, Vanadium, L-arginine, L-Citrulline, L-ornithine, Glutathione, Cystathionine, Superoxide Dismutase, Catalase, N Acetyl L Cysteine, Alpha GPC, and Choline, as well as NAD+, Curcumin and Berberine, these have broad applicability to disease. Pregnenolone is strong because it is the original physiological inhibitor of Choline Kinase. 33 DMB or Grapeseed Oil or Grapeseed Extract, makes this combination really strong. Adding Histidine and Cysteine make it even stronger. If you take it as a supplement and use it in bathing… Read more »

Terry Lynch
Guest

Thanks so much for the treasure chest of Lecithin and acetycholine interactions and preponderant choline deficiency pathophysiology. Recently a multifocal motor neuropathy(less than 4000 diagnosed US) case showed up in my neigborhood falling over from left sided muscle deterioration. She had been taking IgA twice a month with a present cost presently exceeding $20,000 / month since 1990. Within 6 months on a proper choline rich diet, stress free gardening in a peaceful place, and one tablespoon of granular Lecithin (always purchased direct from manufacturer and kept in the freezer to avoid oxidation!!) her neurologist in NY was flabergasted, astonished,… Read more »

Research
Guest

B Vitamins and Folic Acid cannot replace inadequate Choline, these may increase the volume of Homocysteine recycling into Methionine and it is possible that these are complicating factors. Physiology prefers its energy as Hydride fracked from Choline and Methyl Groups, producing ATP from these. The reason sugar is so pleasing and sweetness of sugar is correlated to Hydride content of sweeteners and molecules. Obtaining meals without adequate Choline results in a net decrease in Choline because Choline is required to produce Digestive Fluids through the activity of MDR2. The answer is choline, protecting PEMT from being in inhibited and the… Read more »

fd
Guest
fd

well, thank you so much Researcher. The information was a lot and it took me some days to read and study all, but it was worth it.

Joel Greene
Guest
Joel Greene

I have acetylcholine esterase deficiency. My C-reactive protein test was “7”. Do I have a higher level of inflammation or does this mean that a serious health telatefevent is imminent?

David
Guest

No discussion about choline, phosphatidylcholine or lecithin (or even L-carnitine, betaine or TMG) consumption is complete without a thorough discussion of TMAO (Trimethylamine N-oxide).

There are several studies on this subject. Here is one:

Gut flora metabolism of phosphatidylcholine promotes cardiovascular… – PubMed – NCBI
http://www.ncbi.nlm.nih.gov/pubmed/21475195

As far as popular media, Dr. Oz, who used to recommend L-Carnitine supplements, has retracted that recommendation. When it comes to TMAO, there is little difference between L-Carnitine and choline supplements.

Dan
Guest
Dan

HI Christi, I’m not a doctor, but a patient like you. I’ve also found that I need to avoid nightshade foods big time or I get muscle cramps, twitching, and just overall overstimulation. High acetylcholine levels can cause anxiety as well due to that overstimulation. I recently found a study that showed a connection between B12 deficiency and low acetylcholinesterase levels, suggesting that perhaps B12 may help increase the breakdown of acetylcholine. The same with l-carnitine. Treatment with l-carnitine helped restore acetylcholinesterase levels in aged rats. Not sure if the same thing occurs in humans, but it’s worth noting that… Read more »

Christi
Guest

I’m hoping to connect the dots between this and BCHE gene rs1799807, cholinesterase inhibitors, nightshade intolerance. Anne Wright has written on it.

I’ve had a decrease in POTS like symptoms, mysthenia gravis like symptoms, CFS/Fibromyalgia, just from eliminating Nightshade foods.

I like eggs but they seem to make me sick to my stomach, I wish I could benefit from a choline supplement I still have anxiety and memory problems.

racerbiker
Guest
racerbiker

Christi, I am on a similar path to find the connection between choline, acetylcholine, cholinesterase inhibitors and nightshades. I cannot tolerate anything that contains choline. Have you made any progress?

researcher
Guest
researcher

Follow up with a health services practitioner, organization or Advisor when using any of the clinical information presented here for the care of onself or others. Continue to seek interactions with health advisors during supplementation or therapy. The literature is clear, foregoing Choline obtainment is not recommended because organ dysfunction and the metabolic syndrome exhibited in all disease rely upon doing exactly that, depriving physiology of Choline. Trimethylamine is produced from Choline and Phosphatidylcholine as well as L Carnitine and perhaps TMG being metabolized through proteolytic processes or lysing metaboling processes, but Trimethylamine is the result of either less than… Read more »

Kathrynn
Guest
Kathrynn

I have been having some intermittent ptosis (eyelid drooping) and myasthenia gravis was suggested as a possibility. I put together several conversations about myasthenia gravis with a word I remembered from my detox report “acetylation”, so I ran my 23andme results for PEMT and I am +/+ homozygous TT for the rs7946 and also rs4646408 is +/+ TT as well. Of the rest of the PEMT there are 22 heterozygous, 10 normal, and 13 not genotyped. According to my detox report I am probably a slow acetylator since I have NAT2 R197Q rs1799930 AA +/+. Also in the detox report… Read more »

john
Guest
john

I am diagnosed with myasthenia gravis.and undergone post thymectomy. Can I use this lecithin as a supplement. Will I see any improvement in my situation. Thanks in advance.

James
Guest
James

Great article but I think there is an error.

We are only interested in the raw egg yolk portion of the egg which would be about 17 grams. This means there is roughly 116 mg of lecithin per raw egg yolk and not 389 mg.

melvin
Guest
melvin

the snp you named above for pemt is the one my results say is the normal one TT and shows green not red colored like the mthfr.

Why would the wild type normal be a higher risk for fatty liver?

Tiffany
Guest
Tiffany

I got a prenatal diagnosis of trisomy 21 for my last child and read a study in a mouse model of T21 where pre- and perinatal choline improved symptoms. I started 3 g/day choline at ~20 weeks and my now 8 month old was born with no major health issues and is progressing age appropriately in terms of meeting milestones. We have continued choline during breastfeeding. I would love to find out the level of methylation on my son’s 21st chromosome as I’m sure that the high dose choline has decreased the severity of effects from the additional chromosome.